Recombinant Human ADAMTS6 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ADAMTS6-3748H
• Product Overview: ADAMTS6 MS Standard C13 and N15-labeled recombinant protein (NP_922932) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Expression of this gene may be regulated by the cytokine TNF-alpha.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 122.7 kDa
• AA Sequence: MEILWKTLTWILSLIMASSEFHSDH RLSYSSQEEFLTYLEHYQLTIPIRV DQNGAFLSFTVKNDKHSRRRRSMDP IDPQQAVSKLFFKLSAYGKHFHLNL TLNTDFVSKHFTVEYWGKDGPQWKH DFLDNCHYTGYLQDQRSTTKVALSN CVGLHGVIATEDEEYFIEPLKNTTE DSKHFSYENGHPHVIYKKSALQQRH LYDHSHCGVSDFTRSGKPWWLNDTS TVSYSLPINNTHIHHRQKRSVSIER FVETLVVADKMMVGYHGRKDIEHYI LSVMNIVAKLYRDSSLGNVVNIIVA RLIVLTEDQPNLEINHHADKSLDSF CKWQKSILSHQSDGNTIPENGIAHH DNAVLITRYDICTYKNKPCGTLGLA SVAGMCEPERSCSINEDIGLGSAFT IAHEIGHNFGMNHDGIGNSCGTKGH EAAKLMAAHITANTNPFSWSACSRD YITSFLDSGRGTCLDNEPPKRDFLY PAVAPGQVYDADEQCRFQYGATSRQ CKYGEVCRELWCLSKSNRCVTNSIP AAEGTLCQTGNIEKGWCYQGDCVPF GTWPQSIDGGWGPWSLWGECSRTCG GGVSSSLRHCDSPAPSGGGKYCLGE RKRYRSCNTDPCPLGSRDFREKQCA DFDNMPFRGKYYNWKPYTGGGVKPC ALNCLAEGYNFYTERAPAVIDGTQC NADSLDICINGECKHVGCDNILGSD AREDRCRVCGGDGSTCDAIEGFFND SLPRGGYMEVVQIPRGSVHIEVREV AMSKNYIALKSEGDDYYINGAWTID WPRKFDVAGTAFHYKRPTDEPESLE ALGPTSENLIVMVLLQEQNLGIRYK FNVPITRTGSGDNEVGFTWNHQPWS ECSATCAGGVQRQEVVCKRLDDNSI VQNNYCDPDSKPPENQRACNTEPCP PEWFIGDWLECSKTCDGGMRTRAVL CIRKIGPSEEETLDYSGCLTHRPVE KEPCNNQSCPPQWVALDWSECTPKC GPGFKHRIVLCKSSDLSKTFPAAQC PEESKPPVRIRCSLGRCPPPRWVTG DWGQCSAQCGLGQQMRTVQCLSYTG QASSDCLETVRPPSMQQCESKCDST PISNTEECKDVNKVAYCPLVLKFKF CSRAYFRQMCCKTCQGHTRTRPLEQ KLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif 6 [ Homo sapiens (human) ]
• Official Symbol: ADAMTS6
• Synonyms: ADAMTS6; ADAM metallopeptidase with thrombospondin type 1 motif, 6; a disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6; A disintegrin and metalloproteinase with thrombospondin motifs 6; a disintegrin and metalloproteinase with thrombospondin motifs 6; ADAM TS6; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6; ADAM-TS6; ADAMTS-6; ADAM-TS 6
• Gene ID: 11174
• mRNA Refseq: NM_197941
• Protein Refseq: NP_922932
• MIM: 605008
• UniProt ID: Q9UKP5

Reviews

11/12/2021

The ADAMTS6 protein product received was as advertised, top quality and good value for money.

03/08/2021

The technician guided me through the process, which led to satisfactory results.

12/18/2020

Prompt delivery helped me get satisfactory experimental results in a short period of time.

Q&As

What is the relationship between ADAMTS6 and ADAMTS10 expression?

ADAMTS10 negatively regulates ADAMTS6, and ADAMTS6 can compensate for the loss of ADAMTS10.

What diseases is ADAMTS6 used to study?

ADAMTS6 has been associated with studies of esophageal squamous cell carcinoma and breast cancer, among other diseases.

What proteins does ADAMTS6 have the highest homology to?

ADAMTS6 has the highest homology to ADAMTS10 and ADAMTSL2.

What diseases is ADAMTS6 involved in?

ADAMTS6 is involved in cardiovascular diseases.

In which tissues is ADAMTS6 mainly expressed?

ADAMTS6 is highly expressed in the liver, kidney, and skeletal muscle.