Recombinant Human ADAMTS9 protein, His & T7-tagged

• Cat.No.: ADAMTS9-1758H
• Product Overview: Recombinant Human ADAMTS9 aa. (Cys1727~Leu1935 (Accession # Q9P2N4)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.
• Source: E. coli
• Species: Human
• Tag: His & T7
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 26.8kDa
• Protein length: Cys1727~Leu1935 (Accession # Q9P2N4)
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >90%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
• Reconstitution: Reconstitute in sterile ddH2O.
• Isoelectric Point: 8.4

Gene Information

• Gene Name: ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif 9 [ Homo sapiens (human) ]
• Official Symbol: ADAMTS9
• Synonyms: ADAMTS9; ADAM metallopeptidase with thrombospondin type 1 motif 9; A disintegrin and metalloproteinase with thrombospondin motifs 9; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9
• Gene ID: 56999
• mRNA Refseq: NM_001318781.1
• Protein Refseq: NP_001305710.1
• UniProt ID: Q9P2N4

Reviews

08/16/2022

The ADAMTS9 proteins purchased from your company is suitable for ELISA.

07/12/2022

Patient customer service and detailed answers to my questions.

11/21/2021

The quality of the product is high and the price is cheap, it is worth buying again.

11/21/2020

The technical expert will follow up on the progress of my experiments and provide constructive advice on the problems that arise in my experiments.

Q&As

What pathological processes is ADAMTS9 involved in?

ADAMTS9 is involved in ECM degradation, angiogenesis, tumours, cardiovascular diseases and many other physiological pathological processes.

What diseases is ADAMTS9 involved in?

ADAMTS9 involved in rectal, pancreatic cancer and other diseases.

Which protein does ADAMTS9 share the highest homology with?

ADAMTS9 has the highest homology with ADAMTS20.

What are the effects of ADAMTS9 deficiency?

Loss of ADAMTS9 resulted in shortened cilia and defective sonic hedgehog signaling.

Where is the cellular localization of ADAMTS9?

ADAMTS9 is localized near the basal body of primary cilia in the cytoplasm.