Recombinant Human ADAMTSL3 protein, GST-tagged
Cat.No. : | ADAMTSL3-3672H |
Product Overview : | Recombinant Human ADAMTSL3 protein(616-720 aa), fused to GST tag, was expressed in E. coli. |
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Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 100mM GSH. |
Protein length : | 616-720 aa |
AA Sequence : | TERPCLLEACDESPASRELDIPLPE DSETTYDWEYAGFTPCTATCLGGHQ EAIAVCLHIQTQQTVNDSLCDMVHR PPAMSQACNTEPCPPRWHVGSWGPC SATCG |
Purity : | 90%, by SDS-PAGE with Coomassie Brilliant Blue staining. |
Storage : | Short-term storage: Store at 2-8°C for (1-2 weeks). Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles. |
Reconstitution : | Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage. Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage. |
Gene Name : | ADAMTSL3 ADAMTS-like 3 [ Homo sapiens ] |
Official Symbol : | ADAMTSL3 |
Synonyms : | ADAMTSL3; ADAMTS-like 3; ADAMTS-like protein 3; KIAA1233; punctin 2; ADAMTSL-3; punctin-2; a disintegrin-like and metalloprotease domain with thrombospondin type I motifs-like 3; MGC150716; MGC150717; |
Gene ID : | 57188 |
mRNA Refseq : | NM_207517 |
Protein Refseq : | NP_997400 |
MIM : | 609199 |
UniProt ID : | P82987 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (15)
Ask a questionADAMTSL3 protein levels can be measured using a range of laboratory techniques including ELISA, Western blotting, and mass spectrometry. More advanced imaging techniques such as immunohistochemistry and confocal microscopy can also be used to visualize ADAMTSL3 expression in cells and tissues.
Research into the role of ADAMTSL3 in cardiovascular disease is ongoing. While there is currently no evidence to suggest that ADAMTSL3 protein can be used to treat cardiovascular disease, future research may identify potential therapeutic targets.
ADAMTSL3 protein can be studied using various techniques such as western blotting, immunohistochemistry, and gene expression analysis. Animal models, such as knockout mice and xenograft models, can also be used to study the role of ADAMTSL3 in disease development and its potential as a therapeutic target. Additionally, in vitro experiments can be performed using cell lines to study the effects of ADAMTSL3 on cellular processes such as cell adhesion, migration, and proliferation.
The ADAMTS protein family comprises 19 members, including ADAMTS1-18 and ADAMTSL1-5. These proteins are involved in a diverse range of processes including ECM assembly and remodeling, angiogenesis, inflammation, and coagulation.
At present, there is no evidence to suggest that ADAMTSL3 protein can be used to treat connective tissue disorders. However, research into the role of ADAMTSL3 in connective tissue biology is ongoing.
ADAMTSL3 protein is involved in the regulation of cellular processes such as cell adhesion, migration, and proliferation, as well as various developmental processes and tissue homeostasis. ADAMTSL3 also plays a role in the formation and maintenance of extracellular matrix structures such as connective tissues, cartilage, and bone.
There is currently no evidence to suggest that ADAMTSL3 protein can improve wound healing. However, ongoing research into the role of ADAMTSL3 in tissue repair may identify potential therapeutic targets for enhancing wound healing.
While there are no current therapeutic applications for ADAMTSL3 protein, research is being conducted to determine potential therapeutic targets for various medical conditions.
ADAMTSL3 has been implicated in various cancer types since it is involved in the regulation of cell adhesion, migration, and proliferation. Studies have shown that there is a decreased expression of ADAMTSL3 in several types of cancers such as breast, prostate, colon, and ovarian cancer. Its downregulation is correlated with advanced tumor stage, invasion, and poor prognosis.
The reduced expression of ADAMTSL3 in cancer cells suggests that it may play a role in tumor development and progression. Therefore, ADAMTSL3 protein may serve as a promising therapeutic target in cancer. Preclinical studies have shown that upregulation of ADAMTSL3 can inhibit cancer cell proliferation, invasion, and metastasis.
ADAMTSL3 protein is expressed in a range of tissues including the heart, lungs, kidneys, and skeletal muscle. It is also expressed in a number of cell types including fibroblasts, smooth muscle cells, and endothelial cells.
At present, there is no evidence to suggest that ADAMTSL3 protein can be used to treat muscular disorders. However, ongoing research into the role of ADAMTSL3 in muscle biology may identify potential therapeutic targets.
While there is evidence to suggest that ADAMTSL3 is involved in tumor development and metastasis, it is unclear whether ADAMTSL3 protein could be used to prevent or treat cancer. Further research is required to determine if ADAMTSL3 protein could be a viable therapeutic target in cancer treatment.
At present, there are no drugs specifically targeting ADAMTSL3 protein. However, there are drugs that target other proteins involved in connective tissue biology, some of which may be relevant to ADAMTSL3-related conditions.
At present, there are no ongoing clinical trials specifically targeting ADAMTSL3 protein. However, there are several clinical trials investigating the use of drugs that target the ECM and fibrillin in various connective tissue disorders, some of which may be relevant to ADAMTSL3-related conditions.
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