Recombinant Human ADAMTSL3 Protein, His (Fc)-Avi-tagged

• Cat.No.: ADAMTSL3-2426H
• Product Overview: Recombinant Human ADAMTSL3 with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Human
• Tag: His (Fc)-Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: ADAMTSL3 ADAMTS-like 3 [ Homo sapiens ]
• Official Symbol: ADAMTSL3
• Gene ID: 57188
• mRNA Refseq: NM_207517.2
• Protein Refseq: NP_997400.2
• MIM: 609199
• UniProt ID: P82987

Q&As

What methods can be used to measure ADAMTSL3 protein levels?

ADAMTSL3 protein levels can be measured using a range of laboratory techniques including ELISA, Western blotting, and mass spectrometry. More advanced imaging techniques such as immunohistochemistry and confocal microscopy can also be used to visualize ADAMTSL3 expression in cells and tissues.

Can ADAMTSL3 protein be used to treat cardiovascular disease?

Research into the role of ADAMTSL3 in cardiovascular disease is ongoing. While there is currently no evidence to suggest that ADAMTSL3 protein can be used to treat cardiovascular disease, future research may identify potential therapeutic targets.

How is ADAMTSL3 protein studied in the laboratory?

ADAMTSL3 protein can be studied using various techniques such as western blotting, immunohistochemistry, and gene expression analysis. Animal models, such as knockout mice and xenograft models, can also be used to study the role of ADAMTSL3 in disease development and its potential as a therapeutic target. Additionally, in vitro experiments can be performed using cell lines to study the effects of ADAMTSL3 on cellular processes such as cell adhesion, migration, and proliferation.

What are some other members of the ADAMTS protein family?

The ADAMTS protein family comprises 19 members, including ADAMTS1-18 and ADAMTSL1-5. These proteins are involved in a diverse range of processes including ECM assembly and remodeling, angiogenesis, inflammation, and coagulation.

Can ADAMTSL3 protein be used to treat connective tissue disorders?

At present, there is no evidence to suggest that ADAMTSL3 protein can be used to treat connective tissue disorders. However, research into the role of ADAMTSL3 in connective tissue biology is ongoing.

What are the physiological functions of ADAMTSL3 protein?

ADAMTSL3 protein is involved in the regulation of cellular processes such as cell adhesion, migration, and proliferation, as well as various developmental processes and tissue homeostasis. ADAMTSL3 also plays a role in the formation and maintenance of extracellular matrix structures such as connective tissues, cartilage, and bone.

Can ADAMTSL3 protein be used to improve wound healing?

There is currently no evidence to suggest that ADAMTSL3 protein can improve wound healing. However, ongoing research into the role of ADAMTSL3 in tissue repair may identify potential therapeutic targets for enhancing wound healing.

What therapeutic applications are being explored for ADAMTSL3 protein?

While there are no current therapeutic applications for ADAMTSL3 protein, research is being conducted to determine potential therapeutic targets for various medical conditions.

What role does ADAMTSL3 protein play in cancer?

ADAMTSL3 has been implicated in various cancer types since it is involved in the regulation of cell adhesion, migration, and proliferation. Studies have shown that there is a decreased expression of ADAMTSL3 in several types of cancers such as breast, prostate, colon, and ovarian cancer. Its downregulation is correlated with advanced tumor stage, invasion, and poor prognosis.

Can ADAMTSL3 protein be used as a therapeutic target in cancer?

The reduced expression of ADAMTSL3 in cancer cells suggests that it may play a role in tumor development and progression. Therefore, ADAMTSL3 protein may serve as a promising therapeutic target in cancer. Preclinical studies have shown that upregulation of ADAMTSL3 can inhibit cancer cell proliferation, invasion, and metastasis.

Is ADAMTSL3 protein expressed in specific tissues or cell types?

ADAMTSL3 protein is expressed in a range of tissues including the heart, lungs, kidneys, and skeletal muscle. It is also expressed in a number of cell types including fibroblasts, smooth muscle cells, and endothelial cells.

Can ADAMTSL3 protein be used to treat muscular disorders?

At present, there is no evidence to suggest that ADAMTSL3 protein can be used to treat muscular disorders. However, ongoing research into the role of ADAMTSL3 in muscle biology may identify potential therapeutic targets.

Can ADAMTSL3 protein be used to prevent or treat cancer?

While there is evidence to suggest that ADAMTSL3 is involved in tumor development and metastasis, it is unclear whether ADAMTSL3 protein could be used to prevent or treat cancer. Further research is required to determine if ADAMTSL3 protein could be a viable therapeutic target in cancer treatment.

Are there any drugs currently available that target ADAMTSL3 protein?

At present, there are no drugs specifically targeting ADAMTSL3 protein. However, there are drugs that target other proteins involved in connective tissue biology, some of which may be relevant to ADAMTSL3-related conditions.

Are there any ongoing clinical trials involving ADAMTSL3 protein?

At present, there are no ongoing clinical trials specifically targeting ADAMTSL3 protein. However, there are several clinical trials investigating the use of drugs that target the ECM and fibrillin in various connective tissue disorders, some of which may be relevant to ADAMTSL3-related conditions.