Recombinant Human ADD1, His-tagged
Cat.No. : | ADD1-3338H |
Product Overview : | Alpha-adducin (ADD1) |
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Description : | Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. |
Source : | E. Coli or Yeast |
Species : | Human |
Tag : | His |
Form : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Protein length : | 737 |
Purity : | >90% |
Notes : | Small volumes of ADD1 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice. |
Storage : | Store at -20 degree C. For extended storage, store at -20 or -80 degree C. |
Storage Buffer : | PBS pH 7.4, 50% glycerol |
Warning : | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name : | ADD1 adducin 1 (alpha) [ Homo sapiens ] |
Official Symbol : | ADD1 |
Synonyms : | ADD1; adducin 1 (alpha); alpha-adducin; erythrocyte adducin alpha subunit; ADDA; MGC3339; MGC44427; |
Gene ID : | 118 |
mRNA Refseq : | NM_001119 |
Protein Refseq : | NP_001110 |
MIM : | 102680 |
UniProt ID : | P35611 |
Chromosome Location : | 4p16.3 |
Pathway : | Activation of Chaperone Genes by XBP1(S), organism-specific biosystem; Activation of Chaperones by IRE1alpha, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apopto |
Function : | actin binding; actin filament binding; calmodulin binding; metal ion binding; protein heterodimerization activity; protein homodimerization activity; spectrin binding; transcription factor binding; |
Products Types
◆ Recombinant Protein | ||
ADD1-178R | Recombinant Rat ADD1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ADD1-339M | Recombinant Mouse ADD1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ADD1-491H | Recombinant Human ADD1 Protein, His-tagged | +Inquiry |
ADD1-70R | Recombinant Rhesus Macaque ADD1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Add1-492M | Recombinant Mouse Add1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
ADD1-9017HCL | Recombinant Human ADD1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionSpecific antibodies or probes can be developed to visualize the localization of ADD1 in live cells or tissues.
Altering the expression level or activity of ADD1 can affect cellular processes like cell proliferation, differentiation, or apoptosis.
The expression of ADD1 can change under different physiological or pathological conditions.
ADD1 exhibits subcellular localization in various cellular compartments, such as the nucleus or cytoplasm.
ADD1 interacts with specific binding proteins or partners in a context-dependent manner.
The tissue-specific expression pattern of ADD1 varies across organs and cell types.
ADD1 undergoes post-translational modifications, including phosphorylation and acetylation, which can impact its activity and stability.
There may exist small molecule inhibitors or activators that can modulate ADD1's function, with distinct mechanisms of action.
Specific domains or motifs within ADD1 are responsible for its functional activities.
ADD1 regulates downstream target genes or signaling pathways that contribute to its biological functions.
Customer Reviews (3)
Write a reviewHighly effective in detecting and quantifying the expression levels of fusion proteins in protein expression analysis.
Highly specific in detecting the target protein in tissue sections in immunohistochemistry experiments.
Demonstrates high selectivity and sensitivity in detecting protein-protein interactions in pull-down assays.
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