Recombinant Human ADP-Ribosylation Factor-Like 15, His-tagged

• Cat.No.: ARL15-6893H
• Product Overview: Recombinant human ARL15 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 25 kDa.

Specification

• Description: ARL15, also known as ARFRP2, belongs to the ARF family. ARFs are important in eukaryotic vesicular trafficking pathways and play an essential role in the activation of phospholipase D. ARL15 variants influence levels of Acrp30, an adipocyte-derived protein that is particularly heritable and inversely associated with risk of type 2 diabetes mellitus and coronary heart disease.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl.
• Molecular Mass: 25 kDa (224aa), confirmed by MALDI-TOF
• Protein length: 1-204aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MSDLRITEAF LY MDYLCFRA LCCKGPPPAR PEYDLVCIGL TGSGKTSLLS KLCSESPDNV VSTTGFSIKA VPFQNAILNV KELGGADNIR KYWSRYYQGS QGVIFVLDSA SSEDDLEAAR NELHSALQHP QLCTLPFLIL ANHQDKPAAR SVQEIKKYFE LEPLARGKRW ILQPCSLDDM DALKDSFSQL INLLEEKDHE AVRM
• Purity: >85% by SDS-PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4℃ short term (1-2 weeks). For long term storage, aliquot and store at -20℃ or -70℃. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: ARL15 ADP-ribosylation factor-like 15 [ Homo sapiens ]
• Official Symbol: ARL15
• Synonyms: ARL15; ADP-ribosylation factor-like 15; ADP ribosylation factor related protein 2 , ARFRP2; ADP-ribosylation factor-like protein 15; FLJ20051; ARF-related protein 2; ADP-ribosylation factor related protein 2; ADP-ribosylation factor-related protein 2; ARFRP2
• Gene ID: 54622
• mRNA Refseq: NM_019087
• Protein Refseq: NP_061960
• UniProt ID: Q9NXU5
• Chromosome Location: 5p15.2
• Function: GTP binding; nucleotide binding

Reviews

12/06/2022

Their technical expertise and experience in the field allow them to provide invaluable guidance and assistance.

09/30/2022

They have a deep understanding of the ARL15 protein and can provide valuable insights into its characteristics, properties, and optimal experimental conditions.

11/16/2020

the manufacturer offers outstanding technical support, serving as a valuable resource to resolve any issues that may arise during my research.

07/31/2020

This guidance can help researchers design and execute their experiments more effectively, ensuring reliable and accurate results.

06/14/2020

The manufacturer's support can play a crucial role in assisting researchers throughout their trials.

06/30/2018

They can offer insights on experimental design, optimal usage protocols, and troubleshoot any challenges that may arise during the course of the trial.

07/11/2017

In addition to these experimental benefits, the manufacturer of ARL15 protein plays a vital role in supporting researchers.

08/13/2016

Its potency and specificity make it a valuable tool for studying specific biological pathways or mechanisms.

Q&As

Can ARL15 be therapeutically targeted for any diseases?

Given its potential involvement in cancer development, ARL15 could be a potential therapeutic target for specific types of cancers. However, more studies are necessary to evaluate its suitability as a target for therapeutic intervention.

Is ARL15 conserved across different species?

ARL15 shows varying levels of conservation across species. While it is found in mammals, its presence in other organisms may differ. Comparative genomics studies can provide insights into the conservation of ARL15.

Has ARL15 been linked to any developmental processes?

There is limited knowledge about the involvement of ARL15 in developmental processes. Further research is required to explore its potential role in development and organogenesis.

Are there any genetic variants or mutations in the ARL15 gene associated with diseases?

Currently, there is limited information on specific genetic variants or mutations in the ARL15 gene associated with diseases. However, genome-wide association studies (GWAS) or genetic screenings could potentially provide insights into any disease-related variants.

Is ARL15 predominantly localized to a specific cellular compartment?

ARL15 is known to localize to different cellular compartments depending on the context. It has been observed in the cytoplasm, plasma membrane, and within vesicular structures involved in protein trafficking.

Are there any known interacting proteins or protein complexes that involve ARL15?

Yes, several proteins have been identified as interacting partners of ARL15. These include components of the cytoskeleton, such as actin, as well as proteins involved in vesicle transport and membrane trafficking pathways.

Has ARL15 been linked to any cellular processes or signaling pathways?

ARL15 has been associated with several cellular processes, including cell migration, cytoskeletal dynamics, and membrane trafficking. It may also play a role in downstream signaling pathways, although more research is needed to fully understand its involvement.

Are there any known functional studies or characterizations of ARL15?

While some functional studies have been conducted on ARL15, its exact role and mechanisms of action are still being explored. Further research is needed to fully understand its function.

Is ARL15 associated with any diseases or disorders?

There is evidence to suggest that ARL15 may be involved in certain diseases. For example, it has been implicated in the development of breast cancer and prostate cancer.