Recombinant Human ADSL Protein (M1-L484), His/Strep tagged
Cat.No. : | ADSL-0289H |
Product Overview : | Recombinant Human 6His-strepII-TEV-GG-ADSL(M1-L484 end) Protein was expressed in E. coli. |
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Description : | Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. |
Source : | E. coli |
Species : | Human |
Tag : | His/Strep |
Form : | Liquid |
Protein Length : | M1-L484 |
Endotoxin : | < 0.01 EU per μg of the protein |
Purity : | 90% |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles |
Storage Buffer : | Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol |
Shipping : | It is shipped out with blue ice. |
Gene Name : | ADSL adenylosuccinate lyase [ Homo sapiens (human) ] |
Official Symbol : | ADSL |
Synonyms : | ADSL; adenylosuccinate lyase; adenylosuccinase; ASL; AMPS; ASASE; |
Gene ID : | 158 |
mRNA Refseq : | NM_000026 |
Protein Refseq : | NP_000017 |
MIM : | 608222 |
UniProt ID : | P30566 |
Products Types
◆ Recombinant Protein | ||
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Adsl-549M | Recombinant Mouse Adsl Protein, MYC/DDK-tagged | +Inquiry |
ADSL-369M | Recombinant Mouse ADSL Protein, His (Fc)-Avi-tagged | +Inquiry |
ADSL-7077C | Recombinant Chicken ADSL | +Inquiry |
◆ Lysates | ||
ADSL-8995HCL | Recombinant Human ADSL 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionGenetic variations or mutations in the Adsl gene can affect the stability or function of Adsl protein, leading to metabolic disorders like Adenylosuccinate Lyase Deficiency.
Adsl protein can interact with other proteins and form complexes, including the formation of multiprotein complexes involved in purine metabolism.
The enzymatic activity and substrate specificity of Adsl protein are attributed to its unique structural features, including conserved domains and active sites.
Experimental techniques such as enzymatic assays and substrate analysis have been used to characterize the enzymatic activity of Adsl protein.
Currently, there are no specific pharmacological agents targeting Adsl protein. However, understanding its regulation and functional implications may lead to the development of potential therapeutic approaches for related conditions.
Adsl protein is primarily involved in the de novo synthesis of purine nucleotides and participates in the purine salvage pathway.
The cellular localization of Adsl protein is primarily in the cytoplasm, but it can also be found in the nucleus under specific conditions.
Dysregulation or dysfunction of Adsl protein can disrupt purine metabolism, leading to metabolic disorders such as Adenylosuccinate Lyase Deficiency, which affects neurological and developmental processes.
The expression of Adsl protein is regulated at both the transcriptional and post-transcriptional levels by various factors, such as transcription factors and microRNAs.
Adsl protein activity can be modulated by cellular factors and cofactors, including magnesium ions and ATP.
Customer Reviews (3)
Write a reviewExploring protein-protein interactions involved in apoptosis signaling.
Characterizing protein-protein interactions involved in cancer progression.
Determining protein-protein interaction interfaces using X-ray crystallography.
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