Recombinant Human AEBP2 Protein, GST-tagged

• Cat.No.: AEBP2-395H
• Product Overview: Human AEBP2 full-length ORF ( NP_694939.1, 1 a.a. - 295 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: AEBP2 (AE Binding Protein 2) is a Protein Coding gene. Diseases associated with AEBP2 include Waardenburg Syndrome, Type 4A. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin organization. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 59.4 kDa
• AA Sequence: MSSDGEPLSRMDSEDSISSTIMDVD STISSGRSTPAMMNGQGSTTSSSKN IAYNCCWDQCQACFNSSPDLADHIR SIHVDGQRGGVFVCLWKGCKVYNTP STSQSWLQRHMLTHSGDKPFKCVVG GCNASFASQGGLARHVPTHFSQQNS SKVSSQPKAKEESPSKAGMNKRRKL KNKRRRSLPRPHDFFDAQTLDAIRH RAICFNLSAHIESLGKGHSVVFHST VIAKRKEDSGKIKLLLHWMPEDILP DVWVNESERHQLKTKVVHLSKLPKD TALLLDPNIYRTMPQKRLKR
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: AEBP2 AE binding protein 2 [ Homo sapiens ]
• Official Symbol: AEBP2
• Synonyms: AEBP2; AE binding protein 2; zinc finger protein AEBP2; MGC17922; AE-binding protein 2; adipocyte enhancer-binding protein 2; AE(adipocyte enhancer)-binding protein 2
• Gene ID: 121536
• mRNA Refseq: NM_001114176
• Protein Refseq: NP_001107648
• UniProt ID: Q6ZN18

Reviews

03/28/2022

Detecting protein-protein interactions in DNA binding and transcriptional regulation.

07/26/2021

Understanding protein-protein interaction networks in cell death signaling.

02/14/2020

Exploring protein-protein interactions involved in mitochondrial dysfunction.

Q&As

How does dysregulation or dysfunction of AEBP2 protein affect cellular functions or contribute to disease development?

Dysregulation or dysfunction of AEBP2 protein can disrupt cellular processes, including embryonic development or stem cell differentiation, and contribute to the development of developmental disorders or cancer.

What are the tissue-specific expression patterns of AEBP2 protein and the factors that regulate its expression levels?

The tissue-specific expression patterns of AEBP2 protein vary across different organs and cell types. Factors regulating its expression levels include transcriptional control and signaling pathways.

What experimental techniques have been employed to investigate the functional significance of AEBP2 protein?

Experimental techniques such as gene expression analysis, chromatin immunoprecipitation, knockout or overexpression studies, and functional assays have been employed to investigate the functional significance of AEBP2 protein.

What is the molecular function or role of AEBP2 protein in specific cellular processes or molecular pathways?

AEBP2 protein plays a role in various cellular processes, including embryonic development, stem cell regulation, and epigenetic control of gene expression, by modulating chromatin structure and transcriptional activity.

How is the subcellular localization of AEBP2 protein determined, and are there specific mechanisms or targeting sequences involved?

The subcellular localization of AEBP2 protein is determined by specific mechanisms and targeting sequences, which facilitate its transport and localization to specific cellular compartments.

Are there any genetic variations or mutations in the AEBP2 gene that impact the expression or function of AEBP2 protein?

Genetic variations or mutations in the AEBP2 gene may impact the expression or function of AEBP2 protein, potentially contributing to altered cellular processes and disease susceptibility.

Does AEBP2 protein have DNA-binding activity, and if so, what are the target DNA sequences or specific binding motifs?

AEBP2 protein exhibits DNA-binding activity, recognizing specific DNA sequences or binding motifs, such as AT-rich elements, that regulate gene expression and chromatin organization.

Are there any known post-translational modifications or regulatory factors that modulate the activity or stability of AEBP2 protein?

Post-translational modifications, such as phosphorylation or methylation, and regulatory factors modulate the activity or stability of AEBP2 protein, impacting its function and cellular responses.

Does AEBP2 protein interact with other proteins or participate in protein complexes, and if so, what are the functional implications?

AEBP2 protein interacts with other proteins, such as transcription factors or chromatin modifiers, forming protein complexes that influence gene expression and cellular processes.

Are there any specific structural features or domains of AEBP2 protein that are critical for its function or interaction with other molecules?

The structural features or domains of AEBP2 protein, including the DNA-binding domain, transcriptional repression domains, and interaction regions, are critical for its function and interaction with other molecules in cellular processes.