Recombinant Human AEN Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | AEN-759H |
Product Overview : | AEN MS Standard C13 and N15-labeled recombinant protein (NP_073604) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 36.4 kDa |
AA Sequence : | MVPREAPESAQCLCPSLTIPNAKDV LRKRHKRRSRQHQRFMARKALLQEQ GLLSMPPEPGSSPLPTPFGAATATE AASSGKQCLRAGSGSAPCSRRPAPG KASGPLPSKCVAIDCEMVGTGPRGR VSELARCSIVSYHGDVLYDKYIRPE MPIADYRTRWSGITRQHMRKAVPFQ VAQKEILKLLKGKVVVGHALHNDFQ ALKYVHPRSQTRDTTYVPNFLSEPG LHTRARVSLKDLALQLLHKKIQVGQ HGHSSVEDATTAMELYRLVEVQWEQ QEARSLWTCPEDREPDSSTDMEQYM EDQYWPDDLAHGSRGGAREAQDRRN TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | AEN apoptosis enhancing nuclease [ Homo sapiens (human) ] |
Official Symbol : | AEN |
Synonyms : | AEN; apoptosis enhancing nuclease; interferon stimulated exonuclease gene 20kDa like 1, ISG20L1; apoptosis-enhancing nuclease; FLJ12484; FLJ12562; interferon-stimulated 20 kDa exonuclease-like 1; interferon stimulated exonuclease gene 20kDa-like 1; ISG20L1; pp12744; |
Gene ID : | 64782 |
mRNA Refseq : | NM_022767 |
Protein Refseq : | NP_073604 |
MIM : | 610177 |
UniProt ID : | Q8WTP8 |
Products Types
◆ Recombinant Protein | ||
AEN-1066H | Recombinant Human AEN Protein (117-325 aa), His-SUMO-tagged | +Inquiry |
Aen-1546M | Recombinant Mouse Aen Protein, Myc/DDK-tagged | +Inquiry |
AEN-372M | Recombinant Mouse AEN Protein, His (Fc)-Avi-tagged | +Inquiry |
AEN-2438H | Recombinant Human AEN Protein, His (Fc)-Avi-tagged | +Inquiry |
AEN-207R | Recombinant Rat AEN Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
AEN-8992HCL | Recombinant Human AEN 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionThe subcellular localization of AEN protein is determined by specific mechanisms and targeting sequences, which facilitate its transport and localization to specific cellular compartments.
Dysregulation or dysfunction of AEN protein can disrupt cellular functions, such as impaired DNA repair or altered apoptotic responses, and contribute to the development of diseases like cancer or neurodegenerative disorders.
Genetic variations or mutations in the AEN gene may impact the expression or function of AEN protein, potentially influencing cellular processes or disease susceptibility.
AEN protein may interact with other proteins, such as DNA repair factors or apoptotic regulators, forming protein complexes that influence cellular processes such as DNA repair or cell death.
AEN protein is implicated in specific cellular processes such as DNA repair and apoptosis, where it may play a role in maintaining genomic stability or regulating cell survival.
Experimental techniques such as molecular biology, cell biology, and biochemical assays can be employed to investigate the functional significance of AEN protein, including DNA repair assays or apoptosis assays.
Post-translational modifications or regulatory factors that modulate the activity or stability of AEN protein are not currently identified. Further research is necessary to explore these regulatory mechanisms.
The specific structural features or domains critical for the function or interaction of AEN protein are currently unknown, and further studies are needed to determine their role in cellular processes and molecular interactions.
The enzymatic activity or molecular function of AEN protein is currently unknown, and further experimental assays are needed to investigate its activity and molecular roles.
The tissue-specific expression patterns of AEN protein vary across different organs and cell types. Factors regulating its expression levels include transcriptional control and signaling pathways.
Customer Reviews (3)
Write a reviewExploring protein-protein interactions involved in neurotransmitter signaling.
Characterizing protein-protein interactions involved in chromosomal organization.
Determining protein-protein interaction interfaces using F枚rster resonance energy transfer.
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