Recombinant Human AFF4 Protein, GST-tagged
Cat.No. : | AFF4-407H |
Product Overview : | Human AFF4 full-length ORF ( AAH25700.1, 1 a.a. - 365 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 66.6 kDa |
AA Sequence : | MNREDRNVLRMKERERRNQEIQQGE DAFPPSSPLFAEPYKVTSKEDKLSS RIQSMLGNYDEMKDFIGDRSIPKLV AIPKPTVPPSADEKSNPNFFEQRHG GSHQSSKWTPVGPAPSTSQSQKRSS GLQSGHSSQRTSAGSSSGTNSSGQR HDRESYNNSGSSSRKKGQHGSEHSK SRSSSPGKPQAVSSLNSSHSRSHGN DHHSKEHQRSKSPRDPDANWDSPSR VPFSSGQHSTQSFPPSLMSKSNSML QKPTAYVRPMDGQESMEPKLSSEHY SSQSHGNSMTELKPSSKAHLTKLKI PSQPLDASASGDVSCVDEILKEMTH SWPPPLTAIHTPCKTEPSKFPFPTK ESQQSNFGTGEQRLK |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | AFF4 AF4/FMR2 family, member 4 [ Homo sapiens ] |
Official Symbol : | AFF4 |
Synonyms : | AFF4; AF4/FMR2 family, member 4; AF4/FMR2 family member 4; AF5Q31; ALL1 fused gene from 5q31; MCEF; ALL1-fused gene from chromosome 5q31 protein; major CDK9 elongation factor-associated protein; MGC75036; |
Gene ID : | 27125 |
mRNA Refseq : | NM_014423 |
Protein Refseq : | NP_055238 |
MIM : | 604417 |
UniProt ID : | Q9UHB7 |
Products Types
◆ Recombinant Protein | ||
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AFF4-9457H | Recombinant Human AFF4, His-tagged | +Inquiry |
AFF4-696H | Recombinant Human AFF4 | +Inquiry |
◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionThe subcellular localization of AFF4 protein can be experimentally determined using techniques such as immunofluorescence microscopy or subcellular fractionation.
The expression of AFF4 protein is regulated by specific factors and signaling pathways.
Various experimental techniques or assays, such as chromatin immunoprecipitation, RNA-seq, or gene knockdown approaches, have been used to study the functional significance of AFF4 protein.
AFF4 protein may interact with specific molecules or participate in protein complexes, which have functional implications in cellular processes.
Post-translational modifications and regulatory mechanisms may modulate the activity or stability of AFF4 protein.
Genetic variations or mutations in the gene encoding AFF4 protein may impact its expression or function, influencing cellular processes or disease susceptibility.
Dysregulation or dysfunction of AFF4 protein can affect transcriptional regulation, perturb gene expression networks, and contribute to disease development.
AFF4 protein contributes to specific cellular processes such as development, differentiation, or disease progression, and the underlying molecular mechanisms are currently being investigated.
AFF4 protein holds potential as a target for modulating gene expression or disease phenotypes, and further research is needed to explore its implications for therapeutic interventions.
AFF4 protein plays a role in transcriptional elongation or chromatin remodeling, and its function can be investigated using techniques like chromatin immunoprecipitation or gene expression analysis.
Customer Reviews (3)
Write a reviewInvestigating protein-protein interactions in cellular metabolism for energy balance.
Studying protein-protein interactions in cell migration for tissue morphogenesis.
Mapping protein-protein interactions in receptor trafficking for cellular signaling.
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