Recombinant Human AGER, Flag-tagged

• Cat.No.: AGER-3649H
• Product Overview: Total 331 AA, MW: 35.2 kDa (calculated). C-terminal Flag-tag 11 AA (highlighted).

Specification

• Cat. No.: AGER-3649H
• Description: RAGE, the Receptor for Advanced Glycation Endproducts is a 35kD transmembrane receptor of the immunoglobulin super family which was first characterized in 1992 by Neeper et al. It is also called AGER. Its name comes from its ability to bind advanced glycation endproducts (AGE), which include chiefly glycoproteins the glycans of which have been modified non-enzymatically through the Maillard reaction.
• Source: HEK293
• Species: Human
• Form: Filtered (0.4 um) and lyophilized from 0.5 mg/ml in 50 mM Tris-HCl pH 7.5, 50 mM NaCl.
• Research topic: Diabetology - Other Relevant Products, Neural tissue damage markers, Renal disease.
• Purity: >95%
• Reconstitution: Add deionized water to a working concentration approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter this product by appropriate sterile filter before using it in the cell culture.
• Applications: ELISA, Western blotting
• Quality Control Test: BCA to determine quantity of the protein; SDS PAGE to determine purity of the protein.
• Sequences of amino acids: AQNITARIGE PLVLKCKGAP KKPPQRLEWK LNTGRTEAWK VLSPQGGGPW DSVARVLPNG SLFLPAVGIQ DEGIFRCQAM NRNGKETKSN YRVRVYQIPG KPEIVDSASE LTAGVPNKVG TCVSEGSYPA GTLSWHLDGK PLVPNEKGVS VKEQTRRHPE TGLFTLQSEL MVTPARGGDP RPTFSCSFSP GLPRHRALRT APIQPRVWEP VPLEEVQLVV EPEGGAVAPG GTVTLTCEVP AQPSPQIHWM KDGVPLPLPP SPVLILPEIG PQDQGTYSCV ATHSSHGPQE SRAVSISIIE PGEEGPTAGS VGGSGLGTLA AAADYKDDDD K
• Storage: Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. The lyophilized protein remains stable until the expiry date when stored at -20°C.

Gene Information

• Gene Name: AGER advanced glycosylation end product-specific receptor [ Homo sapiens ]
• Official Symbol: AGER
• Synonyms: AGER; advanced glycosylation end product-specific receptor; RAGE; MGC22357; OTTHUMP00000029155; OTTHUMP00000029156; OTTHUMP00000029157; OTTHUMP00000029158; OTTHUMP00000174885; Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products; RAGE isoform delta; RAGE isoform NtRAGE-delta; RAGE isoform sRAGE-delta; receptor for advanced glycosylation end-products
• Gene ID: 177
• mRNA Refseq: NM_001136
• Protein Refseq: NP_001127
• MIM: 600201
• Uniprot ID: Q15109
• Chromosome Location: 6p21.3
• Function: S100 alpha binding; advanced glycation end-product receptor activity; protein binding; receptor activity; transmembrane receptor activity

Reviews

02/26/2022

It's quality was evident in consistent results across replicates.

08/13/2021

 Protein consistently upregulated the expression of tissue-specific markers.

01/20/2020

 Gel electrophoresis bands displayed distinct separation, showcasing the product’s purity.

06/22/2019

It’s consistent outcomes supported reliable statistical analysis.

01/11/2017

Consistency and Compatibility Consistency in the product’s performance bolstered the credibility of our research findings.

Q&As

How does AGER affect bone health?

AGER is involved in bone metabolism and might influence osteoporosis and bone diseases.

Are there diagnostic applications for AGER?

AGER levels might serve as biomarkers for certain diseases, including diabetes.

How does AGER interact with AGEs?

AGER binds AGEs, initiating signaling cascades linked to inflammation, oxidative stress, and tissue damage.

How is AGER implicated in skin aging?

AGER contributes to skin aging through oxidative stress and collagen damage.

What is the AGER protein?

AGER stands for "Advanced Glycosylation End-Product Specific Receptor," a cell surface receptor.

Can the AGER protein impact inflammation?

Yes, AGER activation contributes to inflammation and immune responses.

How does AGER impact wound healing?

AGER activation can impair wound healing through inflammation and oxidative stress.

How does AGER influence neurodegenerative diseases?

AGER contributes to neuroinflammation and might play a role in neurodegeneration.

Can AGER influence kidney function?

AGER contributes to diabetic nephropathy and kidney dysfunction.

How does the AGER protein interact with AGEs?

AGER binds to AGEs, initiating cellular signaling pathways linked to inflammation and oxidative stress.

Can AGER influence lung health?

AGER is implicated in lung diseases and inflammation, such as chronic obstructive pulmonary disease.

Are there therapeutic strategies targeting AGER?

Researchers explore compounds that modulate AGER to mitigate its effects.

How is AGER involved in diabetic complications?

AGER contributes to diabetic complications by promoting inflammation and tissue damage.

How is the AGER protein involved in research?

AGER is studied for its implications in aging, diabetes, and various age-related diseases.

What is the function of the AGER protein?

AGER plays a role in mediating cellular responses to advanced glycation end products (AGEs).

Are there dietary interventions for AGER-related effects?

Consuming a low-AGE diet may help reduce AGER activation and its negative effects.

Can AGER impact immune responses?

AGER activation affects immune cell functions and influences immune responses.

Does AGER affect cardiovascular health?

AGER activation is linked to cardiovascular diseases, including atherosclerosis.

Are there other ligands for the AGER protein?

Yes, besides AGEs, AGER interacts with other ligands like HMGB1 and β-amyloid.

Is AGER research ongoing?

Yes, ongoing research aims to uncover new roles and therapeutic targets related to AGER.