Recombinant Human AGO4 Protein, GST-tagged
Cat.No. : | AGO4-3168H |
Product Overview : | Human EIF2C4 full-length ORF ( NP_060099.2, 1 a.a. - 861 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | This gene encodes a member of the Argonaute family of proteins which contain PAZ and PIWI domains and play an integral role in RNA interference and short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of related family members. [provided by RefSeq, Mar 2017] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 123.5 kDa |
AA Sequence : | MEALGPGPPASLFQPPRRPGLGTVG KPIRLLANHFQVQIPKIDVYHYDVD IKPEKRPRRVNREVVDTMVRHFKMQ IFGDRQPGYDGKRNMYTAHPLPIGR DRVDMEVTLPGEGKDQTFKVSVQWV SVVSLQLLLEALAGHLNEVPDDSVQ ALDVITRHLPSMRYTPVGRSFFSPP EGYYHPLGGGREVWFGFHQSVRPAM WNMMLNIDVSATAFYRAQPIIEFMC EVLDIQNINEQTKPLTDSQRVKFTK EIRGLKVEVTHCGQMKRKYRVCNVT RRPASHQTFPLQLENGQAMECTVAQ YFKQKYSLQLKYPHLPCLQVGQEQK HTYLPLEVCNIVAGQRCIKKLTDNQ TSTMIKATARSAPDRQEEISRLVKS NSMVGGPDPYLKEFGIVVHNEMTEL TGRVLPAPMLQYGGRNKTVATPNQG VWDMRGKQFYAGIEIKVWAVACFAP QKQCREDLLKSFTDQLRKISKDAGM PIQGQPCFCKYAQGADSVEPMFKHL KMTYVGLQLIVVILPGKTPVYAEVK RVGDTLLGMATQCVQVKNVVKTSPQ TLSNLCLKINAKLGGINNVLVPHQR PSVFQQPVIFLGADVTHPPAGDGKK PSIAAVVGSMDGHPSRYCATVRVQT SRQEISQELLYSQEVIQDLTNMVRE LLIQFYKSTRFKPTRIIYYRGGVSE GQMKQVAWPELIAIRKACISLEEDY RPGITYIVVQKRHHTRLFCADKTER VGKSGNVPAGTTVDSTITHPSEFDF YLCSHAGIQGTSRPSHYQVLWDDNC FTADELQLLTYQLCHTYVRCTRSVS IPAPAYYARLVAFRARYHLVDKDHD SAEGSHVSGQSNGRDPQALAKAVQI HHDTQHTMYFA |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | AGO4 argonaute 4, RISC catalytic component [ Homo sapiens (human) ] |
Official Symbol : | AGO4 |
Synonyms : | AGO4; argonaute 4, RISC catalytic component; EIF2C4; eukaryotic translation initiation factor 2C, 4; protein argonaute-4; FLJ20033; KIAA1567; hAgo4; eIF2C 4; eIF-2C 4; argonaute4; |
Gene ID : | 192670 |
mRNA Refseq : | NM_017629 |
Protein Refseq : | NP_060099 |
MIM : | 607356 |
UniProt ID : | Q9HCK5 |
Products Types
◆ Recombinant Protein | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (23)
Ask a questionAGO4 guides small RNAs to DNA targets for methylation.
Research explores AGO4’s role in guiding small RNAs to target sequences for DNA methylation.
Yes, AGO4’s activity leads to the suppression of gene expression through DNA methylation.
AGO4’s role in gene silencing contributes to the modulation of chromatin structure.
AGO4’s role in DNA methylation can influence epigenetic inheritance.
AGO4 participates in heterochromatin formation through gene silencing.
AGO4 interacts with small RNAs, including small interfering RNAs and long non-coding RNAs.
Yes, AGO4’s function can impact cell differentiation and developmental pathways.
Yes, AGO4’s role includes epigenetic regulation through RNA-directed DNA methylation.
Yes, AGO4’s activity can be modulated by cellular stress and environmental changes.
AGO4 guides small RNAs to complementary DNA sequences, leading to DNA methylation.
Yes, AGO4 is essential for normal development and epigenetic regulation.
Research explores whether AGO4’s function is conserved across various organisms.
Yes, AGO4 is a potential target for modulating gene expression and treating diseases.
Yes, AGO4’s role includes transcriptional gene silencing through DNA methylation.
AGO4 dysfunction can be linked to disorders involving aberrant gene regulation.
Yes, AGO4’s function impacts developmental processes through gene regulation.
Yes, AGO4’s role in RNA interference is studied in plant biology contexts.
Research investigates how AGO4 recognizes and interacts with specific DNA sequences.
Research explores AGO4’s possible links to epitranscriptomic modifications.
Yes, post-translational modifications might affect AGO4’s function.
AGO4’s involvement in DNA methylation helps maintain epigenetic memory across generations.
Yes, AGO4 is involved in silencing transposable elements and maintaining genome stability.
Customer Reviews (5)
Write a reviewThe cost-effectiveness of the product, coupled with clear instructions, was advantageous.
The protein product’s innovative features enabled exploration of novel cellular mechanisms.
Consistently obtaining specific outcomes with the protein product validated its importance.
Despite its price, the product’s contributions to our research goals made it invaluable.
The product consistently met our expectations, lending credibility to our findings.
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