Recombinant Human AGTR1 Full Length Transmembrane protein(Nanodisc)

• Cat.No.: AGTR1-982H
• Product Overview: Recombinant Human AGTR1 Full Length Transmembrane protein(P30556), was expressed in HEK293.

Specification

• Source: HEK293
• Species: Human
• Tag: N/A
• Form: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
• Molecular Mass: The human full length AGTR1 protein has a MW of 40.9 kDa.
• Storage: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: AGTR1 angiotensin II receptor, type 1 [ Homo sapiens ]
• Official Symbol: AGTR1
• Synonyms: AGTR1; angiotensin II receptor, type 1; AGTR1B, angiotensin receptor 1B; type-1 angiotensin II receptor; AG2S; AGTR1A; AT1; AT1B; AT2R1; AT2R1A; AT2R1B; HAT1R; AT1AR; AT1BR; angiotensin receptor 1; angiotensin receptor 1B; angiotensin II type-1 receptor; type-1B angiotensin II receptor; AT1R; AGTR1B
• Gene ID: 185
• mRNA Refseq: NM_000685
• Protein Refseq: NP_000676
• MIM: 106165
• UniProt ID: P30556

Reviews

09/28/2022

It's like a ray of sunshine in our experiments, bringing joy and reliable data. A true delight to work with!

09/02/2022

I have been a loyal customer of this supplier for years due to their commitment to delivering proteins of exceptional quality at competitive prices.

01/19/2021

The post-sale services provided detailed technical support and ensured that I had a positive experience with their products.

03/15/2020

Love the affordable price and great quality of the recombinant proteins I purchased!

Q&As

How is AGTR1 involved in the regulation of renal function?

AGTR1 activation in the kidneys leads to vasoconstriction of renal blood vessels, increased sodium reabsorption, and stimulation of aldosterone release, ultimately impacting renal function.

How does AGTR1 contribute to hypertension?

Overactivation of AGTR1 can lead to increased vasoconstriction, sodium retention, and stimulation of aldosterone release, all of which contribute to hypertension.

What are the tissue distribution and expression of AGTR1?

AGTR1 is widely expressed throughout the body, with high levels found in the cardiovascular system, kidneys, and adrenal glands.

Are there genetic variations in AGTR1 associated with disease susceptibility?

Yes, genetic variations in the AGTR1 gene have been associated with increased susceptibility to cardiovascular diseases, hypertension, and other conditions influenced by the renin-angiotensin system.

Can AGTR1 influence inflammatory processes?

AGTR1 activation can modulate inflammatory responses, contributing to inflammation-associated conditions such as atherosclerosis and chronic kidney disease.

How does AGTR1 signal within cells?

Upon angiotensin II binding, AGTR1 activates intracellular signaling pathways, such as G-protein-mediated pathways and the activation of downstream kinases.

How does AGTR1 affect angiogenesis?

AGTR1 activation can promote angiogenesis, the formation of new blood vessels, by stimulating endothelial cell proliferation and migration.

What are the downstream signaling pathways activated by AGTR1?

AGTR1 can activate pathways such as the phosphoinositide 3-kinase (PI3K)/Akt pathway, mitogen-activated protein kinase (MAPK) pathway, and the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway.

Can AGTR1 be involved in cancer progression?

AGTR1 has been implicated in cancer development and progression due to its role in cellular growth, angiogenesis, and inflammation.

How does AGTR1 contribute to oxidative stress?

AGTR1 activation can promote the generation of reactive oxygen species, contributing to oxidative stress and cellular damage.