Recombinant Human AHRR, His-tagged

• Cat.No.: AHRR-3649H
• Product Overview: Aryl hydrocarbon receptor repressor (AHRR)

Specification

• Description: The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Source: E. Coli or Yeast
• Species: Human
• Tag: His
• Form: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Protein length: 701
• Purity: >90%
• Notes: Small volumes of AHRR recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
• Storage Buffer: PBS pH 7.4, 50% glycerol
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: AHRR aryl-hydrocarbon receptor repressor [ Homo sapiens ]
• Official Symbol: AHRR
• Synonyms: AHRR; aryl-hydrocarbon receptor repressor; AHH, AHHR, aryl hydrocarbon receptor regulator; aryl hydrocarbon receptor repressor; bHLHe77; KIAA1234; ahR repressor; dioxin receptor repressor; aryl hydrocarbon hydroxylase regulator; class E basic helix-loop-helix protein 77; AHH; AHHR; MGC167813; MGC176630
• Gene ID: 57491
• mRNA Refseq: NM_001242412
• Protein Refseq: NP_001229341
• MIM: 606517
• UniProt ID: A9YTQ3
• Chromosome Location: 5p15.33
• Function: DNA binding; signal transducer activity

Reviews

06/26/2022

Results were spot-on using their stratified products.

12/01/2021

Friendly service, and the stratified protein delivered.

09/11/2020

The protein enhanced our research.

04/19/2019

Received excellent support and a reliable products.

12/03/2018

The friendly staff helped me choose the right protein.

Q&As

Discuss the impact of AHRR polymorphisms on its function and their association with disease susceptibility?

Genetic variations in AHRR can lead to altered protein function and influence individual susceptibility to diseases influenced by the AHR signaling pathway, such as cancer and immune-related disorders.

How does AHRR affect the susceptibility to environmental carcinogens and toxicants?

AHRR expression can influence an individual's sensitivity to environmental carcinogens and toxicants by modulating AHR activity and downstream gene expression.

How does AHRR expression vary in different tissues and cell types, and what factors influence this variability?

AHRR expression levels can vary among tissues and cell types, depending on the local microenvironment, exposure to specific ligands, and tissue-specific transcriptional regulators.

What is the structural organization of the AHRR protein, and how does it interact with the AHR?

AHRR contains domains that enable its interaction with AHR, such as bHLH (basic helix-loop-helix) and PAS (Per-Arnt-Sim) domains, facilitating the formation of inhibitory complexes with AHR.

Describe the function of AHRR in the AHR signaling pathway?

AHRR acts as a negative regulator of the AHR signaling pathway, inhibiting AHR-mediated gene transcription in response to ligand activation.

What are the molecular mechanisms through which AHRR suppresses AHR-dependent gene expression?

AHRR competes with AHR for binding to the same target genes, effectively blocking AHR-mediated transcription and inhibiting the expression of AHR-responsive genes.

Describe the involvement of AHRR in inflammatory processes and immune responses?

AHRR is implicated in modulating inflammatory responses and immune cell differentiation, affecting the balance between pro-inflammatory and anti-inflammatory signals.

How is AHRR expression regulated, and what are the factors that control its levels in cells?

AHRR expression can be induced by various environmental stimuli, such as exposure to AHR ligands and other stressors. Transcription factors and epigenetic modifications can regulate AHRR gene expression.

Discuss the role of AHRR in xenobiotic metabolism and detoxification?

AHRR plays a crucial role in regulating the expression of genes involved in xenobiotic metabolism and detoxification, contributing to the body's defense against environmental toxins.

How does AHRR participate in the regulation of circadian rhythm and metabolic homeostasis?

AHRR is involved in circadian rhythm regulation and contributes to metabolic homeostasis by influencing the expression of clock genes and metabolic regulators.