Recombinant Human AIFM3 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | AIFM3-2699H |
Product Overview : | AIFM3 MS Standard C13 and N15-labeled recombinant protein (NP_001018070) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 66 kDa |
AA Sequence : | MGGCFSKPKPVELKIEVVLPEKERG KEELSASGKGSPRAYQGNGTARHFH TEERLSTPHPYPSPQDCVEAAVCHV KDLENGQMREVELGWGKVLLVKDNG EFHALGHKCPHYGAPLVKGVLSRGR VRCPWHGACFNISTGDLEDFPGLDS LHKFQVKIEKEKVYVRASKQALQLQ RRTKVMAKCISPSAGYSSSTNVLIV GAGAAGLVCAETLRQEGFSDRIVLC TLDRHLPYDRPKLSKSLDTQPEQLA LRPKEFFRAYGIEVLTEAQVVTVDV RTKKVVFKDGFKLEYSKLLLAPGSS PKTLSCKGKEVENVFTIRTPEDANR VVRLARGRNVVVVGAGFLGMEVAAY LTEKAHSVSVVELEETPFRRFLGER VGRALMKMFENNRVKFYMQTEVSEL RGQEGKLKEVVLKSSKVVRADVCVV GIGAVPATGFLRQSGIGLDSRGFIP VNKMMQTNVPGVFAAGDAVTFPLAW RNNRKVNIPHWQMAHAQGRVAAQNM LAQEAEMSTVPYLWTAMFGKSLRYA GYGEGFDDVIIQGDLEELKFVAFYT KGDEVIAVASMNYDPIVSKVAEVLA SGRAIRKREVETGDMSWLTGKGSTR TRPLEQKLISEEDLAANDILDYKDD DDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | AIFM3 apoptosis inducing factor mitochondria associated 3 [ Homo sapiens (human) ] |
Official Symbol : | AIFM3 |
Synonyms : | AIFM3; apoptosis-inducing factor, mitochondrion-associated, 3; apoptosis-inducing factor 3; AIFL; FLJ30473; apoptosis-inducing factor like; FLJ45137; |
Gene ID : | 150209 |
mRNA Refseq : | NM_001018060 |
Protein Refseq : | NP_001018070 |
MIM : | 617298 |
UniProt ID : | Q96NN9 |
Products Types
◆ Recombinant Protein | ||
Aifm3-1575M | Recombinant Mouse Aifm3 Protein, Myc/DDK-tagged | +Inquiry |
AIFM3-413M | Recombinant Mouse AIFM3 Protein, His (Fc)-Avi-tagged | +Inquiry |
AIFM3-9505H | Recombinant Human AIFM3, His-tagged | +Inquiry |
AIFM3-475H | Recombinant Human AIG1 Protein, GST-tagged | +Inquiry |
AIFM3-6904Z | Recombinant Zebrafish AIFM3 | +Inquiry |
◆ Lysates | ||
AIFM3-8952HCL | Recombinant Human AIFM3 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (14)
Ask a questionYes, AIFM3 has been shown to be upregulated in various cancers, including breast cancer and lung cancer, and its dysregulation has been implicated in cancer progression and metastasis.
Dysregulation of AIFM3 has been implicated in various diseases, including cancer, Alzheimer's disease, and Parkinson's disease.
It is possible that AIFM3 could be used as a biomarker for disease diagnosis or prognosis in the future. However, more research is needed to validate its potential as a biomarker. For example, a recent study has found that AIFM3 expression is decreased in the blood of patients with chronic obstructive pulmonary disease, suggesting that it could be a potential biomarker for this disease.
AIFM3 is a member of the AIF (Apoptosis-Inducing Factor) family of proteins, which also includes AIF and AIFM1. AIFM3 shares some structural and functional similarities with other AIF family proteins, but they have distinct roles in regulating mitochondrial function and cell death processes.
AIFM3 expression is regulated by various transcription factors and epigenetic modifications. For example, the transcription factor NRF2 promotes AIFM3 expression by binding to its promoter region. Histone acetylation and DNA methylation also play a role in the regulation of AIFM3 expression.
There is currently no evidence supporting the use of AIFM3 as a biomarker for cancer diagnosis or prognosis. However, its dysregulation in cancer suggests that it may be a target for cancer therapy.
Yes, there are ongoing studies investigating the role of AIFM3 in various diseases. For example, a recent study has found that AIFM3 expression is decreased in the brains of patients with Alzheimer's disease, suggesting that AIFM3 may play a role in the pathogenesis of this disease. Other studies are investigating the potential of AIFM3 as a therapeutic target for mitochondrial diseases and neurological disorders.
Yes, mutations in the AIFM3 gene have been associated with various mitochondrial diseases, such as mitochondrial encephalomyopathy and mitochondrial DNA depletion syndrome. These diseases are characterized by defects in mitochondrial function and energy metabolism.
AIFM3 expression is regulated at the transcriptional level by various transcription factors, including HIF-1α and NF-κB.
Yes, AIFM3 has been shown to be downregulated during aging, and its dysregulation has been implicated in aging-related degeneration and cellular senescence.
Yes, targeting AIFM3 can be a potential therapeutic strategy for mitochondrial diseases or neurological disorders. For example, increasing AIFM3 expression or activity could improve mitochondrial function and energy metabolism in patients with mitochondrial diseases. In contrast, inhibiting AIFM3 activity could be beneficial in neurological disorders where excessive AIFM3 activity is detrimental, such as in epilepsy.
Various techniques can be used to study AIFM3, including genetic and epigenetic analyses, protein expression and purification, cell culture and functional assays, and mouse models. For example, to study the role of AIFM3 in mitochondrial function, researchers can use techniques such as mitochondrial membrane potential analysis, respiration assays, and ATP production assays.
Yes, mutations in the AIFM3 gene have been associated with various diseases, including autism spectrum disorders and X-linked intellectual disability.
Yes, AIFM3 is a potential target for drug development in various diseases, including cancer and neurodegenerative diseases. However, extensive research is needed to determine the therapeutic potential and safety of targeting AIFM3.
Customer Reviews (4)
Write a reviewIts remarkable purity, consistency, and stability make it the perfect candidate to drive my research forward and produce precise and dependable results.
the manufacturer of the AIFM3 protein offers exceptional technical support, reinforcing the overall excellence of their product.
Their expert assistance effectively addresses any challenges or inquiries that may arise during my experiments, ensuring a seamless workflow and the successful resolution of any issues.
The AIFM3 protein presents itself as an outstanding choice that surpasses my expectations in terms of quality and suitability for my experimental requirements.
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