Recombinant Human ALKBH4, GST-tagged

• Cat.No.: ALKBH4-9585H
• Product Overview: Recombinant Human ALKBH4 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-302a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: ALKBH4 alkB, alkylation repair homolog 4 (E. coli) [ Homo sapiens ]
• Official Symbol: ALKBH4
• Synonyms: 2010004B12Rik; ABH4; Abj4; AlkB, alkylation repair homolog 4 (E. coli); Alkylated DNA repair protein alkB homolog 4; FLJ20013; Probable alpha-ketoglutarate dependent dioxygenase ABH4; RGD1308608; ALKBH4
• Gene ID: 54784
• mRNA Refseq: NM_017621.3
• Protein Refseq: NP_060091.1
• MIM: 613302
• UniProt ID: Q9NXW9
• Chromosome Location: 7q22.1
• Function: metal ion binding;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;oxidoreductase activity, acting on single d

Reviews

03/15/2022

The protein has low cytotoxicity.

07/26/2020

Short half-life and high clearance rate.

02/09/2020

The stability of this protein is relatively good, heat resistance, acid and alkaline resistance and protease degradation test results are very good.

04/21/2019

This protein performed well by testing kinetic parameters such as enzymatic reaction rate, binding affinity and so on.

Q&As

Does ALKBH4 protein play a role in cardiovascular disease?

Current studies have shown that ALKBH4 protein may also play a role in cardiovascular disease.

Is ALKBH4 involved in DNA repair?

At present, it is believed that ALKBH4 protein is related to RNA repair, and its correlation with DNA repair needs to be further confirmed.

In what human diseases does the ALKBH4 protein play a role?

Current studies have found that ALKBH4 protein is related to a variety of cancers, intracranial hemorrhage and other diseases.

What is the biosynthesis mechanism of ALKBH4 protein?

The ALKBH4 protein is transcribed by the ALKBH4 gene and then translated into a protein.

Is the expression of ALKBH4 protein related to the occurrence and development of tumor?

Many studies have shown that the abnormal expression of ALKBH4 protein is related to the occurrence and development of some tumors.

Is ALKBH4 involved in post-translational modification?

There is no clear evidence that ALKBH4 protein is involved in the process of post-translational modification.

Does ALKBH4 protein interact with other genes?

ALKBH4 protein is known to interact with a variety of genes, including other RNA modifying enzymes and DNA damage response genes.

What is the main function of ALKBH4 protein?

ALKBH4 protein is mainly involved in RNA modification and regulation of gene expression.

What are the characteristics of ALKBH4 gene expression pattern?

The expression level of ALKBH4 gene is different in different tissues, and it may be regulated by exogenous factors.

Does ALKBH4 protein participate in cell apoptosis?

The relationship between ALKBH4 protein and apoptosis has not been confirmed.

What are the structural characteristics of ALKBH4 protein?

The structure of ALKBH4 protein is mainly characterized by the presence of methionine modification enzyme active center, which can assist RNA modification.

What chemical exposure is associated with ALKBH4 protein expression?

Current studies suggest that the expression of ALKBH4 protein is affected by environmental factors, including alkylating agents and oxidants.

What are the target molecules of ALKBH4 protein modification?

ALKBH4 protein mainly modifies RNA molecules such as tRNA and rRNA.

What is the application prospect of ALKBH4 protein in cancer treatment?

The ALKBH4 protein has become an important target for some cancer treatments, including drug therapies targeting the protein.