Recombinant Human ALKBH4 Protein, GST-tagged
Cat.No. : | ALKBH4-476H |
Product Overview : | Human ALKBH4 full-length ORF ( NP_060091.1, 1 a.a. - 302 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | ALKBH4 (AlkB Homolog 4, Lysine Demethylase) is a Protein Coding gene. GO annotations related to this gene include actin binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 60.2 kDa |
AA Sequence : | MAAAAAETPEVLRECGCKGIRTCLI CERQRGSDPPWELPPAKTYRFIYCS DTGWAVGTEESDFEGWAFPFPGVML IEDFVTREEEAELVRLMDRDPWKLS QSGRRKQDYGPKVNFRKQKLKTEGF CGLPSFSREVVRRMGLYPGLEGFRP VEQCNLDYCPERGSAIDPHLDDAWL WGERLVSLNLLSPTVLSMCREAPGS LLLCSAPSAAPEALVDSVIAPSRSV LCQEVEVAIPLPARSLLVLTGAARH QWKHAIHRRHIEARRVCVTFRELSA EFGPGGRQQELGQELLRIALSFQGR PV |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ALKBH4 alkB, alkylation repair homolog 4 (E. coli) [ Homo sapiens ] |
Official Symbol : | ALKBH4 |
Synonyms : | ABH4 |
Gene ID : | 54784 |
mRNA Refseq : | NM_017621.3 |
Protein Refseq : | NP_060091.1 |
MIM : | 613302 |
UniProt ID : | Q9NXW9 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (14)
Ask a questionCurrent studies have shown that ALKBH4 protein may also play a role in cardiovascular disease.
At present, it is believed that ALKBH4 protein is related to RNA repair, and its correlation with DNA repair needs to be further confirmed.
Current studies have found that ALKBH4 protein is related to a variety of cancers, intracranial hemorrhage and other diseases.
The ALKBH4 protein is transcribed by the ALKBH4 gene and then translated into a protein.
Many studies have shown that the abnormal expression of ALKBH4 protein is related to the occurrence and development of some tumors.
There is no clear evidence that ALKBH4 protein is involved in the process of post-translational modification.
ALKBH4 protein is known to interact with a variety of genes, including other RNA modifying enzymes and DNA damage response genes.
ALKBH4 protein is mainly involved in RNA modification and regulation of gene expression.
The expression level of ALKBH4 gene is different in different tissues, and it may be regulated by exogenous factors.
The relationship between ALKBH4 protein and apoptosis has not been confirmed.
The structure of ALKBH4 protein is mainly characterized by the presence of methionine modification enzyme active center, which can assist RNA modification.
Current studies suggest that the expression of ALKBH4 protein is affected by environmental factors, including alkylating agents and oxidants.
ALKBH4 protein mainly modifies RNA molecules such as tRNA and rRNA.
The ALKBH4 protein has become an important target for some cancer treatments, including drug therapies targeting the protein.
Customer Reviews (4)
Write a reviewThe protein has low cytotoxicity.
Short half-life and high clearance rate.
The stability of this protein is relatively good, heat resistance, acid and alkaline resistance and protease degradation test results are very good.
This protein performed well by testing kinetic parameters such as enzymatic reaction rate, binding affinity and so on.
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