Recombinant Human ALOX12B 293 Cell Lysate
Cat.No. : | ALOX12B-8898HCL |
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Description : | Antigen standard for arachidonate 12-lipoxygenase, 12R type (ALOX12B) is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection. |
Source : | HEK 293 cells |
Species : | Human |
Components : | This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol). |
Size : | 0.1 mg |
Storage Instruction : | Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment. |
Applications : | ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane. |
Gene Name : | ALOX12B arachidonate 12-lipoxygenase, 12R type [ Homo sapiens ] |
Official Symbol : | ALOX12B |
Synonyms : | ALOX12B; arachidonate 12-lipoxygenase, 12R type; arachidonate 12-lipoxygenase, 12R-type; 12R LOX; 12R-lipoxygenase; epidermis-type lipoxygenase 12; 12R-LOX; |
Gene ID : | 242 |
mRNA Refseq : | NM_001139 |
Protein Refseq : | NP_001130 |
MIM : | 603741 |
UniProt ID : | O75342 |
Chromosome Location : | 17p13.1 |
Pathway : | Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; IL23-mediated signaling events, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Serotonergic synapse, organism-specific biosystem; |
Function : | arachidonate 12-lipoxygenase activity; iron ion binding; lipoxygenase activity; metal ion binding; oxidoreductase activity; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (16)
Ask a questionMutations in the ALOX12B gene may lead to the development of cardiovascular disease, which can affect cardiovascular health.
The ALOX12B gene variant has not been shown to be associated with tumors.
There is no specific treatment for the ALOX12B gene mutation. Treatment is mostly based on symptom relief and reduction of disease progression.
A mutation of the ALOX12B gene can be diagnosed with a genetic test or blood test.
The regulatory mechanisms of ALOX12B gene include transcription factors, miRNA and other regulatory mechanisms.
Mutations in the ALOX12B gene may lead to the development of skin diseases that affect skin health.
ALOX12B gene mutation and liver disease has not been proven to have a clear link.
Current studies have shown that the ALOX12B variant is more common in Asian populations.
ALOX12B encodes the 12R-LOX enzyme, which is involved in biological processes such as lipid metabolism and inflammatory responses.
The polymorphism of ALOX12B gene can affect the activity of the enzyme it encodes, and thus affect related biological processes.
The SNP of ALOX12B gene has not been confirmed to have a clear association with drug metabolism.
The ALOX12B gene plays an important role in the body's inflammatory response and therefore may influence the function of the immune system.
Mutations in the ALOX12B gene have been linked to skin disorders, asthma, cardiovascular disease and more.
The ALOX12B gene can affect biological processes such as fat metabolism in the body, thus affecting body metabolism.
A mutant version of the ALOX12B gene has been linked to a rare inherited fat metabolism disorder called Allen's syndrome.
ALOX12B gene is more expressed in skin, liver, heart, kidney and other organs.
Customer Reviews (3)
Write a reviewALOX12B has good absorbability and high bioavailability.
Highly effective in signal transduction pathways.
Under different environmental conditions,ALOX12B showed good stability.
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