Recombinant Human ALPK2 Protein, GST-tagged

• Cat.No.: ALPK2-492H
• Product Overview: Human ALPK2 partial ORF ( NP_443179, 201 a.a. - 309 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: ALPK2 (Alpha Kinase 2) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity. An important paralog of this gene is ALPK3.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 37.73 kDa
• AA Sequence: DGTSSVTEQGRYKLPTAPEAAENDY PGIQGETRDSHQAREEFASDNLLNM DESVRETEMKLLSGESENSGMSQCW ETAADKRVGGKDLWSKRGSRKSARV RQPGMKGNP
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ALPK2 alpha-kinase 2 [ Homo sapiens ]
• Official Symbol: ALPK2
• Synonyms: ALPK2; alpha-kinase 2; alpha-protein kinase 2; HAK; heart alpha kinase; heart alpha-kinase; heart alpha-protein kinase; FLJ34875; FLJ43253
• Gene ID: 115701
• mRNA Refseq: NM_052947
• Protein Refseq: NP_443179
• UniProt ID: Q86TB3

Reviews

01/08/2022

Excellent crystal quality improvement in crystallization.

08/12/2020

Accurate protein biomarker quantification in clinical samples.

07/31/2019

Sensitive bioactivity assay performance.

Q&As

What is the tissue-specific expression pattern of ALPK2 in humans?

ALPK2 is predominantly expressed in cardiac and skeletal muscle tissues, with lower expression levels observed in other tissues.

Can ALPK2 be pharmacologically targeted with specific inhibitors or activators?

ALPK2 can potentially be targeted pharmacologically using specific inhibitors or activators to modulate its activity and downstream signaling pathways.

What is the impact of ALPK2 mutations on its kinase activity and downstream signaling pathways?

Mutations in ALPK2 can disrupt its kinase activity and alter downstream signaling pathways, leading to pathological conditions.

What are the mechanisms underlying ALPK2-mediated signal transduction and intracellular signaling cascades?

The mechanisms underlying ALPK2-mediated signal transduction involve complex intracellular signaling cascades, including protein phosphorylation, calcium signaling, and gene expression regulation.

How does ALPK2 contribute to the pathogenesis of specific cardiovascular diseases or genetic disorders?

Dysregulation of ALPK2 is associated with various cardiovascular diseases, including cardiomyopathies and arrhythmias, as well as genetic disorders such as familial cardiomyopathy.

How does ALPK2 contribute to the regulation of cardiac function and cardiovascular development?

ALPK2 is critical for proper cardiac function and cardiovascular development, and its dysregulation can lead to various cardiac disorders.

Are there any known substrates or downstream effectors of ALPK2 kinase activity?

ALPK2 has several known substrates and downstream effectors involved in calcium handling, sarcomere organization, and signal transduction.

Can ALPK2 interact with other proteins or form protein complexes in specific cellular contexts?

ALPK2 can interact with other proteins, such as ion channels, scaffolding proteins, and signaling molecules, forming protein complexes that modulate its activity and signaling specificity.

Is ALPK2 involved in cellular processes such as cell cycle progression, apoptosis, or DNA damage response?

ALPK2 is involved in regulating cell cycle progression, apoptosis, and DNA damage response in specific cellular contexts, contributing to cellular homeostasis and disease development.

Does ALPK2 play a role in the regulation of cellular calcium homeostasis or ion channel function?

ALPK2 is implicated in the regulation of calcium homeostasis and ion channel function, particularly in cardiac muscle cells.