Recombinant Human ALPP Protein, His-tagged
Cat.No. : | ALPP-67H |
Product Overview : | Recombinant Human Alkaline Phosphatase is produced by our Mammalian expression system and the target gene encoding Ile23-Asp506 is expressed with a 6His tag at the C-terminus. |
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Description : | Alkaline phosphatase (ALPP) is a membrane protein that exists as a homodimer. ALPP is expressed only in normal-term placenta, endocervix and fallopian tube, as well as in ovarian and proximal gastrointestinal tumors. It has been demonstrated to play a role in various biological processes including cell signaling, long-term potentiation, and cell adhesion. In addition, ALPP has been found to correlate with cognitive function loss in Alzheimer's disease (AD). |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Supplied as a 0.2 um filtered solution of 20mM Tris-Hcl, 150mM NaCl, 0.2mM CaCl2, 10% Glycerol, pH7.5. |
Molecular Mass : | Predicted Molecular Weight: 53.5kDa Apparent Molecular Weight: 45-66.2kDa, reducing conditions. |
AA Sequence : | Ile23-Asp506 |
Endotoxin : | Less than 0.1 EU/ug. |
Purity : | 85% as determined by SDS-PAGE |
Storage : | Store at ≤-70 centigrade, stable for 6 months after receipt. Store at ≤-70 centigrade, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
Quality Statement : | Purity: 85% as determined by SDS-PAGE. |
Shipping : | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
Gene Name : | ALPP alkaline phosphatase, placental [ Homo sapiens (human) ] |
Official Symbol : | ALPP |
Synonyms : | Alkaline phosphatase; placental type; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; ALPP; PLAP; ALP; IAP; ALPI; PLAP-1 |
Gene ID : | 250 |
mRNA Refseq : | NM_001632.5 |
Protein Refseq : | NP_001623.3 |
MIM : | 171800 |
UniProt ID : | P05187 |
Products Types
◆ Recombinant Protein | ||
ALPP-302H | Recombinant Human ALPP Protein, His tagged | +Inquiry |
ALPP-125H | Recombinant Human ALPP Protein, His-tagged | +Inquiry |
ALPP-2558H | Recombinant Human ALPP protein(31-500 aa), C-His-tagged | +Inquiry |
ALPP-329H | Recombinant Human ALPP Protein, His (Fc)-Avi-tagged | +Inquiry |
ALPP-219H | Recombinant Human ALPP protein(Ile23-Asp506), His-tagged | +Inquiry |
◆ Native Protein | ||
ALPP-8347H | Native Human ALPP | +Inquiry |
ALPP-8005H | Native Human Placental Alkaline Phosphatase | +Inquiry |
◆ Lysates | ||
ALPP-8893HCL | Recombinant Human ALPP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionALPP may serve as a diagnostic biomarker for specific diseases, allowing for disease detection and monitoring, and its targeting could hold therapeutic potential in certain pathological conditions.
ALPP participates in the metabolism and turnover of its substrate(s), including the hydrolysis of phosphoester bonds and the regulation of cellular phosphate homeostasis.
ALPP regulates downstream signaling pathways and molecular interactions involved in cellular processes like phosphate metabolism, intracellular signaling, and extracellular matrix remodeling.
ALPP gene expression is regulated by transcription factors, epigenetic modifications, and signaling pathways involved in cellular homeostasis and disease processes.
ALPP is localized to specific cellular compartments, such as the plasma membrane, endoplasmic reticulum, or lysosomes, and its trafficking may be regulated by sorting signals and intracellular transport machinery.
ALPP activity can be modulated by factors such as pH, calcium, and inhibitors, which can affect its catalytic efficiency and cellular functions.
ALPP deficiency or dysregulation is associated with various diseases, including metabolic disorders, bone diseases, and certain cancers, highlighting its pathological implications.
Manipulating ALPP activity and function could offer strategies to modulate cellular processes and disease outcomes, potentially leading to therapeutic interventions and improved patient outcomes.
ALPP expression and activity exhibit dynamic changes during development, cellular differentiation, and disease progression, reflecting its roles in different physiological and pathological contexts.
ALPP shows a tissue-specific expression pattern, with higher levels in tissues such as liver, bone, and kidney, and lower levels in other organs.
Customer Reviews (3)
Write a reviewHigh-throughput screening compatibility.
Consistent protein expression analysis.
Precise protein quantification in ELISA.
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