Recombinant Human ALPP protein, T7/His-tagged
Cat.No. : | ALPP-221H |
Product Overview : | Recombinant human ALPP cDNA (23-506aa, derived from BC009647) fused with T7-His-TEV cleavage site Tag at N-terminal was expressed in E. coli. |
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Source : | E. coli |
Species : | Human |
Tag : | T7/His |
Form : | 1.0 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT. |
AA Sequence : | MASMTGGQQMGRGHHHHHHGNLYFQ GGEFIIPVEEENPDFWNREAAEALG AAKKLQPAQTAAKNLIIFLGDGMGV STVTAARILKGQKKDKLGPEIPLAM DRFPYVALSKTYNVDKHVPDSGATA TAYLCGVKGNFQTIGLSAAARFNQC NTTRGNEVISVMNRAKKAGKSVGVV TTTRVQHASPAGTYAHTVNRNWYSD ADVPASARQEGCQDIATQLISNMDI DVILGGGRKYMFRMGTPDPEYPDDY SQGGTRLDGKNLVQEWLAKRQGARY VWNRTELMQASLDPSVTHLMGLFEP GDMKYEIHRDSTLDPSLMEMTEAAL RLLSRNPRGFFLFVEGGRIDHGHHE SRAYRALTETIMFDDAIERAGQLTS EEDTLSLVTADHSHVFSFGGYPLRG SSIFGLAPGKARDRKAYTVLLYGNG PGYVLKDGARPDVTESESGSPEYRQ QSAVPLDEETHAGEDVAVFARGPQA HLVHGVQEQTFIAHVMAFAACLEPY TACDLAPPAGTTD |
Purity : | >90% by SDS-PAGE |
Applications : | 1. May be used for in vitro ALPP mediated Insulin-like growth factor (IGF) pathway regulation study in stem cell proliferation by coating this protein as matrix protein or use it as soluble factor.2. May be used for protein-protein interaction mapping.3. As enzymatic substrate for various proteases.4. Potential biomarker protein for tumor diagnosis, such as ovarian cancer, et al.5. As immunogen for specific antibody production. |
Storage : | Keep at -80 centigrade for long term storage. Product is stable at 4 centigrade for at least 7 days. |
Gene Name : | ALPP alkaline phosphatase, placental [ Homo sapiens ] |
Official Symbol : | ALPP |
Synonyms : | ALPP; alkaline phosphatase, placental; alkaline phosphatase, placental (Regan isozyme); alkaline phosphatase, placental type; Regan isozyme; PLAP-1; glycerophosphatase; alkaline phosphomonoesterase; placental alkaline phosphatase 1; alkaline phosphatase Regan isozyme; ALP; PALP; PLAP; FLJ61142; |
Gene ID : | 250 |
mRNA Refseq : | NM_001632 |
Protein Refseq : | NP_001623 |
MIM : | 171800 |
UniProt ID : | P05187 |
Chromosome Location : | 2q37.1 |
Pathway : | Folate biosynthesis, organism-specific biosystem; Folate biosynthesis, conserved biosystem; Metabolic pathways, organism-specific biosystem; |
Function : | alkaline phosphatase activity; alkaline phosphatase activity; hydrolase activity; metal ion binding; |
Products Types
◆ Recombinant Protein | ||
ALPP-124H | Recombinant Human ALPP Protein, His-tagged | +Inquiry |
ALPP-2558H | Recombinant Human ALPP protein(31-500 aa), C-His-tagged | +Inquiry |
ALPP-329H | Recombinant Human ALPP Protein, His (Fc)-Avi-tagged | +Inquiry |
ALPP-125H | Recombinant Human ALPP Protein, His-tagged | +Inquiry |
ALPP-219H | Recombinant Human ALPP protein(Ile23-Asp506), His-tagged | +Inquiry |
◆ Native Protein | ||
ALPP-8347H | Native Human ALPP | +Inquiry |
ALPP-8005H | Native Human Placental Alkaline Phosphatase | +Inquiry |
◆ Lysates | ||
ALPP-8893HCL | Recombinant Human ALPP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionALPP may serve as a diagnostic biomarker for specific diseases, allowing for disease detection and monitoring, and its targeting could hold therapeutic potential in certain pathological conditions.
ALPP participates in the metabolism and turnover of its substrate(s), including the hydrolysis of phosphoester bonds and the regulation of cellular phosphate homeostasis.
ALPP regulates downstream signaling pathways and molecular interactions involved in cellular processes like phosphate metabolism, intracellular signaling, and extracellular matrix remodeling.
ALPP gene expression is regulated by transcription factors, epigenetic modifications, and signaling pathways involved in cellular homeostasis and disease processes.
ALPP is localized to specific cellular compartments, such as the plasma membrane, endoplasmic reticulum, or lysosomes, and its trafficking may be regulated by sorting signals and intracellular transport machinery.
ALPP activity can be modulated by factors such as pH, calcium, and inhibitors, which can affect its catalytic efficiency and cellular functions.
ALPP deficiency or dysregulation is associated with various diseases, including metabolic disorders, bone diseases, and certain cancers, highlighting its pathological implications.
Manipulating ALPP activity and function could offer strategies to modulate cellular processes and disease outcomes, potentially leading to therapeutic interventions and improved patient outcomes.
ALPP expression and activity exhibit dynamic changes during development, cellular differentiation, and disease progression, reflecting its roles in different physiological and pathological contexts.
ALPP shows a tissue-specific expression pattern, with higher levels in tissues such as liver, bone, and kidney, and lower levels in other organs.
Customer Reviews (3)
Write a reviewHigh-throughput screening compatibility.
Consistent protein expression analysis.
Precise protein quantification in ELISA.
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