Recombinant Human ALS2CR11 Protein, GST-tagged

• Cat.No.: ALS2CR11-499H
• Product Overview: Human ALS2CR11 full-length ORF ( AAH30659.1, 1 a.a. - 623 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: An autosomal recessive form of juvenile amyotrophic lateral sclerosis was originally mapped to a region of chromosome 2 that includes this gene. The encoded protein contains a calcium-dependent membrane targeting C2 domain. This domain is often found in proteins that are involved in membrane trafficking and signal transduction. [provided by RefSeq, Jun 2016]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 97.5 kDa
• AA Sequence: MEPPQETNRPFSTLDNRSGQVQVLS ATPLLQRNPYSSPDIMHIKGSEASS VPYALNQGTTALPKNKNQEGTGHRL LNMLRKTLKESDSEELEITQETPNL VPFGDVVGCLGIHIKNCRHFMPKIS LQHYANLFIRISINKAVKCTKMCSL LSKNDEKNTVIKFDEVKYFSVQVPR RYDDKRNNILLELIQYDNREKRAFL LGSVQIHLYEVIQKGCFIEEVQVLH GNIFVCRLEVEFMFSYGNFGYGFSH QLKPLQKITEPSMFMNLAPPPERTD PVTKVITPQTVEYPAFLSPDLNVTV GTPAVQSSNQPSVVRLEKLQQQPRE RLEKMKKEYRNLNTWIDKANYLESI LMPKLEHKDSEETNIDEASENTKSN QPEEELENIVGVDIPLVNEEAETTA NELLDNDSEKGLTIPTLNQSDQDNS TADASKNDESTPSPTEVHSLCTISN QETIKAGRIPPLGERQSESMPDRKM KNVFFPLEVKLKDNYPSILKADSSL SEVAFSPKEYNSPSFRPEYIEFKPK FQDCSDKFEDLHDMTSFTHLKKVKS RSRLLGKSSDDIHNHARHSARPYTA PEVNKQRESYSGKFTSRRMVSSGLV HINDKTSDYEMHKMRPKKIKRGY
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ALS2CR11 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11 [ Homo sapiens ]
• Official Symbol: ALS2CR11
• Synonyms: ALS2CR11; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein; FLJ25351; FLJ40332; DKFZp686H0636
• Gene ID: 151254
• mRNA Refseq: NM_001168216
• Protein Refseq: NP_001161688
• UniProt ID: Q53TS8

Reviews

02/15/2022

Minimal cross-reactivity with unrelated proteins.

11/01/2021

Suitable for both qualitative and quantitative protein analysis.

08/25/2020

High stability under different storage conditions.

Q&As

Does ALS2CR11 interact with other proteins or form complexes involved in cellular processes or signaling pathways?

ALS2CR11 may interact with proteins involved in transcriptional regulation, RNA metabolism, or protein-protein interactions, forming complexes critical for its functions.

Are there any genetic variations or mutations in ALS2CR11 associated with neurological disorders or other pathological conditions?

Limited evidence links genetic variations or mutations in ALS2CR11 to neurological disorders or pathological conditions, requiring further investigation.

Can the enzymatic activities of ALS2CR11 be characterized, and what are its potential substrates or targets?

The enzymatic activities of ALS2CR11 are not well-characterized, and further studies are required to determine its potential substrates and targets.

Can therapeutic interventions targeting ALS2CR11 or its associated pathways offer potential strategies for treating neurological disorders or related conditions?

Targeting ALS2CR11 or its associated pathways could hold potential therapeutic strategies for neurological disorders, aiming to restore proper gene expression regulation, neuronal development, or synaptic function.

Does ALS2CR11 play a role in cellular processes such as transcriptional regulation, RNA processing, or protein translation?

ALS2CR11 is implicated in gene expression regulation, potentially influencing transcriptional activity, RNA processing, or translation efficiency.

What are the functional domains or motifs present in ALS2CR11, and how do they contribute to its molecular functions?

ALS2CR11 contains conserved domains, such as DNA-binding domains or RNA-binding motifs, which contribute to its molecular functions and interactions.

Can ALS2CR11 expression or activity be modulated by post-translational modifications, and how do they impact its cellular functions?

Post-translational modifications, such as phosphorylation or acetylation, may regulate ALS2CR11 activity, localization, or its interactions with other proteins.

What is the expression pattern of ALS2CR11 across different tissues and cell types, and are there any specific factors that regulate its expression?

ALS2CR11 exhibits a tissue-specific expression pattern, with higher expression levels observed in certain brain regions and neural tissues.

How does ALS2CR11 contribute to neuronal development or neuronal function, and are there any specific pathways or processes affected by ALS2CR11?

ALS2CR11 is involved in neuronal development and may affect processes such as neuronal differentiation, axon guidance, or synapse formation through its interactions with other molecules.

What are the subcellular localization and distribution patterns of ALS2CR11 within cells, and does it exhibit any organelle-specific associations?

ALS2CR11 localizes to both the nucleus and cytoplasm, with potential associations with specific subcellular compartments such as the nucleolus or stress granules.