Recombinant Human ALX1, His-tagged
Cat.No. : | ALX1-9604H |
Product Overview : | Recombinant Human ALX1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
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Description : | The specific function of this gene has yet to be determined in humans; however, in rodents, it is necessary for survival of the forebrain mesenchyme and may also be involved in development of the cervix. Mutations in the mouse gene lead to neural tube defects such as acrania and meroanencephaly. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Protein length : | 1-326a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Gene Name : | ALX1 ALX homeobox 1 [ Homo sapiens ] |
Official Symbol : | ALX1 |
Synonyms : | ALX1; ALX homeobox 1; CART1, cartilage paired class homeoprotein 1; ALX homeobox protein 1; CART-1; cartilage paired-class homeoprotein 1; FND3; CART1; |
Gene ID : | 8092 |
mRNA Refseq : | NM_006982 |
Protein Refseq : | NP_008913 |
MIM : | 601527 |
UniProt ID : | Q15699 |
Chromosome Location : | 12q21.31 |
Function : | protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription corepressor activity; |
Products Types
◆ Recombinant Protein | ||
ALX1-494M | Recombinant Mouse ALX1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ALX1-0012H | Recombinant Human ALX1 Protein, GST-Tagged | +Inquiry |
ALX1-037H | Recombinant Human ALX1 Protein, GST-HIS-tagged | +Inquiry |
ALX1-4127Z | Recombinant Zebrafish ALX1 | +Inquiry |
ALX1-1581M | Recombinant Mouse ALX1 Protein | +Inquiry |
◆ Lysates | ||
ALX1-8890HCL | Recombinant Human ALX1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionALX1 can be targeted using small molecules, CRISPR/Cas9-based gene editing, or other techniques to modulate its expression or activity, offering potential therapeutic approaches for craniofacial disorders.
ALX1 integrates with signaling pathways such as BMP, Wnt, or FGF signaling to regulate gene expression and cellular behaviors involved in craniofacial development.
ALX1 exhibits dynamic spatial and temporal expression patterns during embryonic development, with specific regulation by signaling pathways, transcription factors, or tissue-specific cues.
ALX1 plays a crucial role in the maintenance and differentiation of cranial neural crest cells, influencing their migration, proliferation, and specification into various craniofacial tissues.
ALX1 interacts with co-regulatory proteins or other transcription factors, forming complexes that modulate gene expression and cellular processes critical for craniofacial morphogenesis.
ALX1 regulates the expression of genes involved in craniofacial development, including those encoding transcription factors, extracellular matrix components, or signaling molecules.
Genetic variations or mutations in ALX1 can disrupt its DNA-binding ability, protein-protein interactions, or transcriptional activity, leading to craniofacial abnormalities or related disorders.
Determining the three-dimensional structure of ALX1 provides insights into its DNA-binding specificity, transcriptional activation domains, and interaction surfaces.
ALX1 regulates downstream effectors or signaling pathways, including those involved in osteogenesis, chondrogenesis, or epithelial-mesenchymal interactions critical for craniofacial morphogenesis.
Studying ALX1 dysfunction in animal models provides insights into the cellular and molecular mechanisms underlying craniofacial malformations, including altered cell migration, proliferation, or differentiation.
Customer Reviews (3)
Write a reviewWide range of available antibody formats for versatility.
Precise quantification of protein-protein interaction affinity.
Time-saving assay procedures without compromising accuracy.
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