ALX4
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Official Full Name
ALX homeobox 4
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Overview
This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones,;limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant;disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of;frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development,;mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing;this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies,;mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use;dual translation initiation sites located 16 codons apart. -
Synonyms
ALX4; ALX homeobox 4; aristaless like homeobox 4 , parietal foramina 2 , PFM2; homeobox protein aristaless-like 4; FPP; KIAA1788; PFM; Aristaless like homeobox 4; aristaless-like homeobox 4; FND2; homeobox protein aristaless like 4; homeodomain transcription factor ALX4; PFM1; PFM2; OTTHUMP00000233417;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ALX4-754H | Recombinant Human ALX4 | Mammalian Cell | His | ||
Human | ALX4-511H | Recombinant Human ALX4 protein, GST-tagged | Wheat Germ | GST | ||
Human | ALX4-8889HCL | Recombinant Human ALX4 293 Cell Lysate | HEK293 | N/A | ||
Human | ALX4-1250HF | Recombinant Full Length Human ALX4 Protein, GST-tagged | In Vitro Cell Free System | GST | 411 amino acids | |
Human | ALX4-2459H-B | Recombinant Human ALX4 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | ALX4-2459H | Recombinant Human ALX4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Chicken | ALX4-5737C | Recombinant Chicken ALX4 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ALX4 involved in several pathways and played different roles in them. We selected most pathways ALX4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ALX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ALX4 has several biochemical functions, for example, DNA binding, HMG box domain binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALX4 itself. We selected most functions ALX4 had, and list some proteins which have the same functions with ALX4. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | KDM5B;ZKSCAN17;ASCL1A;OTPA;TFCP2;ZNF45;ZFP639;TIGD3;H2AFB2 |
HMG box domain binding | PAX3;OLIG2;HOXA3;HOXC4;HHEX;ALX4;CEBPA;UTF1;DLX5 |
RNA polymerase II regulatory region sequence-specific DNA binding | NR1I2;ATF2;ONECUT3;ATF3;ARHGAP35;IRF2;RXRA;SNAI1;ATF4B2 |
protein heterodimerization activity | BAXA;H2AFJ;HAND1;HEXB;PDSS1;YWHAH;PVALB;TPD52L2;HIST1H2AG |
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | ATF1;ESRRG;ALX4;GATA3;ALX1;GABPA;LEF1;ZGLP1;NEUROD2 |
ALX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALX4.
- Q&As
- Reviews
Q&As (10)
Ask a questionALX4 interacts with various co-regulatory proteins and transcription factors, forming complexes that modulate gene expression and cellular processes critical for embryonic development.
ALX4 recognizes specific DNA binding motifs, such as homeobox motifs, and binds to regulatory regions of target genes to regulate their transcriptional activity.
Gain-of-function or loss-of-function mutations in ALX4 can disrupt normal embryonic development, leading to craniofacial abnormalities, limb defects, or skeletal malformations.
ALX4 binding sites are associated with specific epigenetic modifications, such as DNA methylation or histone modifications, which contribute to the regulation of ALX4-mediated transcriptional activity.
ALX4 integrates with signaling pathways, such as BMP, Wnt, or FGF signaling, to modulate gene expression and influence cellular behaviors during embryogenesis.
Pharmacological or genetic modulation of ALX4 activity may have therapeutic implications for craniofacial disorders, skeletal dysplasias, or regenerative medicine, but further studies are needed to explore these possibilities.
ALX4 forms transcriptional complexes with other transcription factors and co-regulators, such as MSX1 or RUNX2, to coordinate gene expression programs essential for craniofacial development, skeletal patterning, and limb morphogenesis.
ALX4 exhibits a dynamic spatiotemporal expression pattern during embryonic development, with prominent expression in craniofacial structures, limb buds, and axial skeleton.
ALX4 regulates cell proliferation, differentiation, and migration during embryogenesis through various molecular mechanisms, including interactions with cell cycle regulators, morphogen gradients, or cytoskeletal components.
ALX4 regulates the expression of genes involved in craniofacial development, skeletal patterning, and limb formation, including those encoding transcription factors, extracellular matrix components, or signaling molecules.
Customer Reviews (3)
Write a reviewCompatibility with small sample volumes for limited samples.
High specificity in protein target identification.
Stable and reliable reagents for reproducible results.
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