Recombinant Human AMBRA1 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | AMBRA1-5951H |
Product Overview : | AMBRA1 MS Standard C13 and N15-labeled recombinant protein (NP_060219) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | AMBRA1 (Autophagy And Beclin 1 Regulator 1) is a Protein Coding gene. Diseases associated with AMBRA1 include Vici Syndrome and Gastric Tubular Adenocarcinoma. Among its related pathways are Neuroscience and Spinocerebellar ataxia. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 132.8 kDa |
AA Sequence : | MKVVPEKNAVRILWGRERGARAMGA QRLLQELVEDKTRWMKWEGKRVELP DSPRSTFLLAFSPDRTLLASTHVNH NIYITEVKTGKCVHSLIGHRRTPWC VTFHPTISGLIASGCLDGEVRIWDL HGGSESWFTDSNNAIASLAFHPTAQ LLLIATANEIHFWDWSRREPFAVVK TASEMERVRLVRFDPLGHYLLTAIV NPSNQQGDDEPEIPIDGTELSHYRQ RALLQSQPVRRTPLLHNFLHMLSSR SSGIQTEPFHPPEQASSTQQDQGLL NRPSAFSTVQSSTAGNTLRNLSLGP TRRSLGGPLSSHPSRYHREIAPGLT GSEWTRTVLSLNSRSEAESMPPPRT SASSVSLLSVLRQQEGGSQASVYTS ATEGRGFPASGLATESDGGNGSSQN NSGSIRHELQCDLRRFFLEYDRLQE LDQSLSGEAPQTQQAQEMLNNNIES ERPGPSHQPTPHSSENNSNLSRGHL NRCRACHNLLTFNNDTLRWERTTPN YSSGEASSSWQVPSSFESVPSSGSQ LPPLERTEGQTPSSSRLELSSSASP QEERTVGVAFNQETGHWERIYTQSS RSGTVSQEALHQDMPEESSEEDSLR RRLLESSLISLSRYDGAGSREHPIY PDPARLSPAAYYAQRMIQYLSRRDS IRQRSMRYQQNRLRSSTSSSSSDNQ GPSVEGTDLEFEDFEDNGDRSRHRA PRNARMSAPSLGRFVPRRFLLPEYL PYAGIFHERGQPGLATHSSVNRVLA GAVIGDGQSAVASNIANTTYRLQWW DFTKFDLPEISNASVNVLVQNCKIY NDASCDISADGQLLAAFIPSSQRGF PDEGILAVYSLAPHNLGEMLYTKRF GPNAISVSLSPMGRYVMVGLASRRI LLHPSTEHMVAQVFRLQQAHGGETS MRRVFNVLYPMPADQRRHVSINSAR WLPEPGLGLAYGTNKGDLVICRPEA LNSGVEYYWDQLNETVFTVHSNSRS SERPGTSRATWRTDRDMGLMNAIGL QPRNPATSVTSQGTETLALQLQNAE TQTEREVPEPGTAASGPGEGEGSEY GASGEDALSRIQRLMAEGGMTAVVQ REQSTTMASMGGFGNNIIVSHRIHR SSQTGTEPGAAHTSSPQPSTSRGLL PEAGQLAERGLSPRTASWDQPGTPG REPTQPTLPSSSPVPIPVSLPSAEG PTVHCELTNNNHLLDGGSSRGDAAG PRGEPRNRTRTRPLEQKLISEEDLA ANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | AMBRA1 autophagy/beclin-1 regulator 1 [ Homo sapiens (human) ] |
Official Symbol : | AMBRA1 |
Synonyms : | AMBRA1; autophagy/beclin-1 regulator 1; activating molecule in BECN1-regulated autophagy protein 1; DCAF3; DDB1 and CUL4 associated factor 3; FLJ20294; KIAA1736; WD repeat domain 94; WDR94; activating molecule in beclin-1-regulated autophagy; MGC33725; |
Gene ID : | 55626 |
mRNA Refseq : | NM_017749 |
Protein Refseq : | NP_060219 |
MIM : | 611359 |
UniProt ID : | Q9C0C7 |
Products Types
◆ Recombinant Protein | ||
AMBRA1-501M | Recombinant Mouse AMBRA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
AMBRA1-332H | Recombinant Human AMBRA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Ambra1-1608M | Recombinant Mouse Ambra1 Protein, Myc/DDK-tagged | +Inquiry |
AMBRA1-01H | Active Recombinant Human AMBRA1 Protein, Myc/DDK-tagged | +Inquiry |
Ambra1-3111M | Recombinant Mouse Ambra1, His-tagged | +Inquiry |
◆ Lysates | ||
AMBRA1-8887HCL | Recombinant Human AMBRA1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAMBRA1 undergoes post-translational modifications, including phosphorylation and ubiquitination, which regulate its interaction with other autophagy-related proteins and modulate its function in autophagy.
AMBRA1 participates in selective autophagy processes, such as mitophagy (selective clearance of damaged mitochondria) and aggrephagy (clearance of protein aggregates), contributing to cellular quality control mechanisms.
AMBRA1 plays a critical role in autophagy regulation by promoting autophagosome formation, facilitating cargo recognition and degradation, and coordinating the activity of other autophagy-related proteins.
AMBRA1 facilitates the clearance of protein aggregates and damaged organelles through autophagy, preventing their accumulation and mitigating cellular damage.
AMBRA1 expression is induced during autophagy by various signaling pathways, including nutrient deprivation, cellular stress, and growth factor signaling.
In addition to its role in autophagy, AMBRA1 interacts with other cellular processes, such as apoptosis and cell proliferation, forming intricate crosstalk that influences cellular fate and homeostasis.
AMBRA1 interacts with Beclin 1, ULK1, and ATG proteins through protein-protein interactions, forming complexes that regulate autophagy initiation and autophagosome formation.
Depletion of AMBRA1 leads to impaired autophagy activity, resulting in the accumulation of damaged proteins and organelles and compromised cellular homeostasis.
AMBRA1 promotes autophagosome formation by regulating the nucleation and elongation steps, ensuring proper assembly of the autophagy machinery and cargo sequestration.
The activity of AMBRA1 in autophagy is modulated by upstream signaling pathways, including mTORC1, AMPK, and MAPK pathways, which integrate nutrient availability and cellular stresses.
Customer Reviews (3)
Write a reviewEasy integration into multi-omics workflows for comprehensive analysis.
Wide dynamic range for accurate quantification of protein changes.
Low false-positive rate in target protein identification.
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