Recombinant Human AOC2 Protein, His-tagged
Cat.No. : | AOC2-176H |
Product Overview : | Recombinant Human AOC2 Protein (Glu509-Phe756) with N-His tag was expressed in E. coli. |
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Description : | Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. |
Source : | E. coli |
Species : | Human |
Tag : | N-His |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 31.7 kDa Accurate Molecular Mass: 32 kDa |
Protein length : | Glu509-Phe756 |
Purity : | > 90% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Storage Buffer : | PBS, pH7.4, containing 0.01% SKL, 1 mM DTT, 5% Trehalose and Proclin300. |
Reconstitution : | Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL. Do not vortex. |
Gene Name : | AOC2 amine oxidase, copper containing 2 (retina-specific) [ Homo sapiens (human) ] |
Official Symbol : | AOC2 |
Synonyms : | AOC2; amine oxidase, copper containing 2 (retina-specific); retina-specific copper amine oxidase; DAO2; RAO; SSAO; semicarbazide-sensitive amine oxidase |
Gene ID : | 314 |
mRNA Refseq : | NM_001158 |
Protein Refseq : | NP_001149 |
MIM : | 602268 |
UniProt ID : | O75106 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (18)
Ask a questionAOC2 has important application potential in many fields such as biological science and medical field, and has a very wide application prospect.
AOC2 has potential therapeutic effects in the treatment of kidney disease and cancer.
At present, the specific application of AOC2 in tumor therapy still needs to be further studied.
At present, the clinical study of AOC2 in the treatment of tumor has not been conclusive, and further research is needed.
The dose of AOC2 needs to be adjusted individually according to the clinical situation. In general, use strictly according to the doctor's advice.
Yes, some mature production technologies have been developed and the corresponding processes have been applied on a large scale.
AOC2 is a recombinant human protein from exons, and its structure and function conform to physiological characteristics.
AOC2 has been implicated in the occurrence and development of certain kidney diseases, as well as in the occurrence and development of tumors.
AOC2 has higher biological activity and stability compared with other similar biological products.
Yes, AOC2 can be mass-produced through cell culture, genetic engineering and other technologies.
It is necessary to go through the relevant approval process to obtain the approval of the national regulatory authority for use.
It is necessary to solve relevant technical problems by strengthening research and developing new process technologies.
AOC2 is used in many fields such as kidney disease treatment and tumor treatment.
AOC2 can alleviate physiological processes such as renal fibrosis and inflammatory response, and has a potential role in the prevention and treatment of kidney diseases.
No studies have shown that AOC2 has adverse effects on human reproductive health.
The regulation of AOC2 on intracellular oxygen molecules is related to anti-oxidative stress, and can also affect cell cycle, proliferation and apoptosis.
Yes, AOC2 needs to undergo relevant clinical trials to evaluate its efficacy and safety.
Recombinant AOC2 proteins may have some side effects, such as headache, nausea, pain, etc., but they are relatively rare.
Customer Reviews (3)
Write a reviewImmunogenicity of AOC2 is very weak, does not cause an immune response, and is very safe.
The catalytic activity of AOC2 is very excellent, and it can be widely used in various chemical reactions, and has high practical value.
Repeatability is very good, can reduce unnecessary repeated experiments, improve the efficiency of the experiment.
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