Recombinant Human APBA3, His-tagged

• Cat.No.: APBA3-7825H
• Product Overview: Recombinant Human Amyloid beta A4 Precursor ProteinBinding Family A Member 3/APBA3 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1Leu138) of Human APBA3 fused with a 6His tag at the Cterminus.

Specification

• Description: Amyloid beta A4 Precursor ProteinBinding Family A Member 3 (APBA3) is an adapter protein that belongs to the X11 family. APBA3 contains 2 PDZ (DHR) domains and 1 PID domain and interacts with the Alzheimer"s disease amyloid precursor protein.. APBA3 is believed to be involved in signal transduction processes. Unlike X11alpha and beta which are generally neuronal proteins, APBA3 is widely expressed in all tissues examined with lower levels in brain and testis. It binds to the cytoplasmic domain of amyloid protein (APP) in vivo and may modulate processing of the betaamyloid precursor protein (APP) and hence formation of betaAPP.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized from a 0.2 μM filtered solution of 20mM PB ,150mM NaCl, pH 7.2
• Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
• Notes: For research use only.
• Storage: Lyophilized protein should be stored at less than 20°C. though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C. for 2-7 days.Aliquots of reconstituted samples are stable at less than 20°C. for 3 months.

Gene Information

• Gene Name: APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 [ Homo sapiens ]
• Official Symbol: APBA3
• Synonyms: APBA3; amyloid beta (A4) precursor protein-binding, family A, member 3; amyloid beta A4 precursor protein-binding family A member 3; mint3; X11 like 2; X11L2; mint-3; X11-like 2 protein; adapter protein X11gamma; neuron-specific X11L2 protein; neuronal munc18-1-interacting protein 3; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2); MGC:15815
• Gene ID: 9546
• mRNA Refseq: NM_004886
• Protein Refseq: NP_004877
• MIM: 604262
• UniProt ID: O96018
• Chromosome Location: 19p13.3
• Function: beta-amyloid binding; enzyme binding; protein binding

Reviews

07/05/2021

The short half-life and high clearance characteristics of APBA3 allow it to better interact with other drugs, so as to better play the effect of combination therapy.

06/20/2021

Green production process of APBA3 realizes the efficient use of energy, reduces energy consumption, reduces carbon emissions, and is very friendly to the environment.

02/19/2021

APBA3 is highly stable and reproducible, which brings great convenience to our experiments. The results of each experiment are very consistent, giving us more confidence in its quality and reliability.

09/14/2020

Stability of APBA3 is very good, and the results remain consistent after repeated use, showing good product quality.

Q&As

What is the application prospect of APBA3 in neurodegenerative diseases?

The application prospects of APBA3 in neurodegenerative diseases are still uncertain, but its involvement in synaptic transmission and neurotransmitter regulation may have potential value in the treatment of such diseases.

Do APBA3 proteins interact with other proteins?

Yes, the APBA3 protein can interact with other proteins, including those involved in synaptic transmission and neurotransmitter regulation.

What are the potential clinical applications of APBA3 ?

Recombinant APBA3 protein has potential clinical applications, including neurodegenerative diseases, cognitive disorders and cancer treatment.

Does APBA3 have side effects?

The side effects of APBA3 are currently unclear and require further clinical studies and validation.

What are the structural and functional characteristics of APBA3 protein?

APBA3 protein is a multi-domain protein whose main function is to participate in the regulation of signal transduction and synaptic transmission of neurotransmitters.

What is the effect of APBA3 on cognitive function?

Recombinant APBA3 may have a positive effect on cognitive function, improving cognition by regulating synaptic transmission and neurotransmitter balance.

How is the clinical trial of APBA3 progressing?

At present, the clinical trial of APBA3 is under way, and the specific progress needs to consult the relevant clinical research institutions.

What is the mechanism of action of APBA3 in cancer therapy?

The mechanism of action of APBA3 in cancer therapy is not clear, but some studies suggest that it may be involved in the regulation of signal transduction pathways, thereby inhibiting tumor growth and metastasis.

Can APBA3 be administered orally to patients?

Whether the recombinant APBA3 protein can be administered orally to patients still needs further study. At present, it is mainly administered by injection.

How is APBA3 synthesized and purified?

Recombinant APBA3 proteins are usually synthesized in cells by genetic engineering techniques and then purified and purified, for example using affinity chromatography.