Recombinant Human APBB1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: APBB1-2405H
• Product Overview: APBB1 MS Standard C13 and N15-labeled recombinant protein (NP_663722) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 77 kDa
• AA Sequence: MSVPSSLSQSAINANSHGGPALSLP LPLHAAHNQLLNAKLQATAVGPKDL RSAMGEGGGPEPGPANAKWLKEGQN QLRRAATAHRDQNRNVTLTLAEEAS QEPEMAPLGPKGLIHLYSELELSAH NAANRGLRGPGLIISTQEQGPDEGE EKAAGEAEEEEEDDDDEEEEEDLSS PPGLPEPLESVEAPPRPQALTDGPR EHSKSASLLFGMRNSAASDEDSSWA TLSQGSPSYGSPEDTDSFWNPNAFE TDSDLPAGWMRVQDTSGTYYWHIPT GTTQWEPPGRASPSQGSSPQEESQL TWTGFAHGEGFEDGEFWKDEPSDEA PMELGLKEPEEGTLTFPAQSLSPEP LPQEEEKLPPRNTNPGIKCFAVRSL GWVEMTEEELAPGRSSVAVNNCIRQ LSYHKNNLHDPMSGGWGEGKDLLLQ LEDETLKLVEPQSQALLHAQPIISI RVWGVGRDSGRDFAYVARDKLTQML KCHVFRCEAPAKNIATSLHEICSKI MAERRNARCLVNGLSLDHSKLVDVP FQVEFPAPKNELVQKFQVYYLGNVP VAKPVGVDVINGALESVLSSSSREQ WTPSHVSVAPATLTILHQQTEAVLG ECRVRFLSFLAVGRDVHTFAFIMAA GPASFCCHMFWCEPNAASLSEAVQA ACMLRYQKCLDARSQASTSCLPAPP AESVARRVGWTVRRGVQSLWGSLKP KRLGAHTPTRTRPLEQKLISEEDLA ANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: APBB1 amyloid beta precursor protein binding family B member 1 [ Homo sapiens (human) ]
• Official Symbol: APBB1
• Synonyms: APBB1; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); RIR; amyloid beta A4 precursor protein-binding family B member 1; Fe65; stat-like protein; adaptor protein FE65a2; FE65; MGC:9072
• Gene ID: 322
• mRNA Refseq: NM_145689
• Protein Refseq: NP_663722
• MIM: 602709
• UniProt ID: O00213

Reviews

12/08/2021

APBB1 they produce has strong anti-pollution ability and is safe to use.

02/21/2020

Band position of APBB1 in Western blot was consistent with the expectation, showing good target recognition ability.

12/14/2019

Catalytic activity of APBB1 is very strong, which can significantly improve the yield of chemical reactions and reduce costs, and its economic value is outstanding.

08/03/2019

After using this APBB1, my experiment repeatability is very good, which is convenient for subsequent data analysis and experimental operation.

Q&As

Does APBB1 involve signal transduction pathways?

APBB1 are involved in mitochondrial and Wnt signaling pathways.

What is the function and mechanism of APBB1 ?

Recombinant APBB1 protein is a transcription factor associated with biological processes such as protein breakdown, signaling, and the cell cycle. Its main function is to participate in the regulation of transcription and RNA stability.

Is the APBB1 gene associated with genetic susceptibility to cancer?

Mutations in the APBB1 gene are thought to be a risk gene for certain cancers and diseases such as Alzheimer's disease.

Is there gene tailoring of APBB1 in humans? If so, what is their molecular phenotype?

The APBB1 gene is known to have multiple tailoring exons. In humans, there may be variable splicing of APBB1 gene.

Are there any drugs that target APBB1 ? If so, what is their mechanism of action?

There are currently no drugs on the market that target the APBB1. At the same time, some researchers are exploring molecules related to APBB1 to develop drugs to treat diseases associated with it.

What is the mechanism of action of APBB1 in the treatment of Alzheimer's disease?

APBB1 is involved in regulating the metabolism and transport of Alzheimer's disease-associated Aβ peptides and may be a therapeutic target for Alzheimer's disease.

In what diseases does recombinant APBB1 play an important role?

The APBB1 has been studied in relation to many diseases, including Alzheimer's disease, cancer and cardiovascular disease.

In which organs is the expression of APBB1 high?

APBB1 is highly expressed in tissues such as brain, heart and lung.

Has any study confirmed the correlation between APBB1 and the mutation of the gene encoding APP?

Variations in both the APBB1 gene and the APP gene are considered risk genes for Alzheimer's disease.

What are the biological pathways associated with APBB1 ?

APBB1 is associated with the amyloid precursor protein metabolic pathway (APP).

Is there any modern technology that can achieve the effect of treating and preventing related diseases by gene editing APBB1?

The use of gene editing technology to study APBB1 to treat and prevent related diseases is a research hotspot in recent years.

Is there any research to prove that APBB1 can play an important role in anticancer therapy?

APBB1 has been shown to be involved in a number of cell cycle and apoptosis pathways, so it may hold promise as a new target for cancer therapy.

Is there a specific antibody that can be used to detect APBB1 ?

There are currently no specific antibodies available for the detection of APBB1 .

Are there any diseases associated with APBB1 gene mutation? If so, what are they?

Mutations in the APBB1 gene are thought to be associated with diseases such as cancer and Alzheimer's disease.

What is the mechanism of action of APBB1 in cardiovascular disease?

APBB1 is involved in signaling pathways in the occurrence and development of cardiovascular diseases such as myocardial hypertrophy and myocardial fibrosis.

Is APBB1 related to apoptosis? If so, what are their mechanisms?

APBB1 may be involved in the regulation of apoptosis.

What is the role of APBB1 in tumor growth?

APBB1 protein may act as a tumor inhibitor and participate in the regulation of cell cycle progression and apoptosis.

Are there any studies to control dementia symptoms associated with Alzheimer's disease by regulating the recombinant APBB1 protein?

It has been shown that the impairment of cognitive function associated with Alzheimer's disease can be mitigated by regulating the APBB1.

Is there any research to prove that APBB1 can promote the regeneration of cardiovascular organs?

At present, there are no studies to prove the mechanism of APBB1 promoting cardiovascular organ regeneration.