Recombinant Human APBB2 protein, His & GST-tagged

• Cat.No.: APBB2-8172H
• Product Overview: Recombinant Human APBB2 aa. (Asp413~Pro758 (Accession# Q92870)) fused with N-terminal His & GST tag was produced in E. coli cells.

Specification

• Description: The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants.
• Source: E. coli
• Species: Human
• Tag: His & GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 68.7kDa
• Protein length: Asp413~Pro758 (Accession# Q92870)
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >90%
• Characteristic: The isoelectric point is 6.7.
• Applications: SDS-PAGE; WB; ELISA; IP
• Stability: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage Buffer: Supplied as lyophilized form in 20mM Tris, 500mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
• Reconstitution: Reconstitute in ddH2O.

Gene Information

• Gene Name: APBB2 amyloid beta precursor protein binding family B member 2 [ Homo sapiens (human) ]
• Official Symbol: APBB2
• Synonyms: FE65L; FE65L1; Fe65-like 1; protein Fe65-like 1; amyloid beta A4 precursor protein-binding family B member 2
• Gene ID: 323
• mRNA Refseq: NM_001166050.1
• Protein Refseq: NP_001159522.1
• UniProt ID: Q92870

Reviews

10/05/2022

Labeling effect of APBB2 showed excellent performance in Western blot, which can be used for fluorescence labeling.

09/14/2022

Reproducibility of this APBB2 is very good, which can reduce unnecessary repeated experiments and improve experimental efficiency.

10/17/2020

APBB2 produced by them is easy to preserve and has no problem in long-term preservation.

Q&As

Is there a link between APBB2 and genetic factors?

It is not known whether there is a direct relationship between APBB2 s and genetic factors, but complex genetic and environmental interactions may be involved.

Is the therapeutic effect of APBB2 dose-dependent?

The therapeutic effect of APBB2 may be dose-dependent, but the specific dose-response relationship needs further study.

Does APBB2 affect patients' daily life?

The effect of APBB2 varies from patient to patient and may have some impact on daily life, but the specific situation needs to be evaluated on an individual basis.

How to evaluate the efficacy of APBB2 ?

Evaluating the efficacy of APBB2 usually requires clinical trials and animal studies to observe its impact on disease models and therapeutic efficacy.

Can APBB2 be used as a target for new drug development?

APBB2 may have some potential as a target for new drug development, but further studies and validation are needed.

Is there a link between APBB2 and other brain diseases?

There is no clear link between the APBB2 and other brain diseases, but future research may reveal more.

Does the efficacy of APBB2 change over time?

The efficacy of recombinant APBB2 protein may vary over time, possibly due to factors such as its metabolism, clearance and receptor regulation in vivo.

How to synthesize APBB2 ?

The synthesis of APBB2 usually requires the introduction of APBB2 gene into the appropriate expression system through genetic engineering technology, and then obtained through expression and purification.

Is it possible for the APBB2 to be recognized by the immune system and produce an immune response?

There may be a risk of recognition by the immune system and an immune response when treated with the APBB2, but this needs to be assessed on a case-by-case basis.

What are the possible side effects of APBB2 ?

There have been no definite reports of side effects. However, more safety assessments are needed in research and clinical applications.

Is recombinant APBB2 used in the treatment of Alzheimer's disease?

At present, there is no clear evidence that the APBB2 is used in the treatment of Alzheimer's disease, but the protein may have some potential applications in related research.

Are there other similar s with similar effects to APBB2?

There are no clear reports of similar s with similar roles to APBB2, but future studies may uncover related proteins.

Are there any drugs related to APBB2 in clinical trials?

There are no confirmed reports of drugs related to APBB2 in clinical trials, but there may be future advances in related research.

Can APBB2 be delivered through drug pathway?

APBB2 can be delivered through drug routes, such as injection, but the specific pathway needs to be further validated and optimized.

Is there no alternative to APBB2 ?

No clear replacement for the APBB2 has yet been found, but future research may reveal proteins with similar functions.

What is the estimated cost and time to develop the APBB2 ?

The estimated cost and time of developing APBB2 will involve many factors, including the strength of researchers, funds and technology, and it is difficult to give a specific estimate.

What is the scientific research value of APBB2 ?

The APBB2 can serve as an important tool for studying nervous system function and related diseases, helping to gain insight into their mechanisms and search for potential treatments.

What are the clinical applications of APBB2 ?

APBB2 has potential clinical applications in the treatment of neurosystem-related diseases, such as Alzheimer's disease.

How does APBB2 affect the function of the nervous system?

APBB2 may influence nervous system function by regulating neuronal activity and synaptic function.

Can APBB2 treat other neurosystem-related diseases?

Although recombinant APBB2 protein may have some potential in the treatment of neurosystem-related diseases, its role in the treatment of other neurosystem-related diseases needs further investigation.