Recombinant Human APOOL protein, GST-tagged

• Cat.No.: APOOL-720H
• Product Overview: Human APOOL full-length ORF ( NP_940852.3, 1 a.a. - 268 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a protein which contains an apolipoprotein O superfamily domain. This domain is found on proteins in circulating lipoprotein complexes. [provided by RefSeq, Sep 2011]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 55.6 kDa
• AA Sequence: MAAIRMGKLTTMPAGLIYASVSVHA AKQEESKKQLVKPEQLPIYTAPPLQ SKYVEEQPGHLQMGFASIRTATGCY IGWCKGVYVFVKNGIMDTVQFGKDA YVYLKNPPRDFLPKMGVITVSGLAG LVSARKGSKFKKITYPLGLATLGAT VCYPVQSVIIAKVTAKKVYATSQQI FGAVKSLWTKSSKEESLPKPKEKTK LGSSSEIEVPAKTTHVLKHSVPLPT ELSSEAKTKSESTSGATQFMPDPKL MDHGQSHPEDIDMYSTRS
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: APOOL apolipoprotein O-like [ Homo sapiens ]
• Official Symbol: APOOL
• Synonyms: APOOL; apolipoprotein O-like; chromosome X open reading frame 33 , CXorf33, FAM121A, family with sequence similarity 121A; AAIR8193; UNQ8193; family with sequence similarity 121A; CXorf33; FAM121A; MGC129748
• Gene ID: 139322
• mRNA Refseq: NM_198450
• Protein Refseq: NP_940852
• UniProt ID: Q6UXV4

Reviews

02/24/2020

With expert assistance and reliable product quality, researchers can conduct their experiments with confidence, enabling them to contribute to advancements in the field and potentially improve future therapeutic interventions.

04/10/2019

This includes rigorous quality control measures to ensure the consistency and purity of the protein, thereby reducing variability in the experimental outcomes.

02/10/2018

by utilizing APOOL protein in trials and collaborating with a supportive manufacturer, researchers can gain access to a versatile tool that can aid in their understanding of angiogenesis and vascular biology.

02/01/2018

Their comprehensive knowledge about APOOL protein and its applications can assist researchers in optimizing protocols and ensuring reliable results.

Q&As

Are there any known mutations in the APOOL gene associated with disease?

Currently, there is limited information on mutations in the APOOL gene and their association with diseases. Future studies and genetic analyses might uncover potential disease-related mutations and their implications.

Are there any genetic variations of APOOL protein associated with disease susceptibility?

Currently, there is limited information on genetic variations of APOOL protein and their association with disease susceptibility. More research is required to investigate potential genetic links to diseases and understand the functional implications of these variations.

How does APOOL protein contribute to apoptosis?

APOOL protein interacts with ALG-2, a calcium-binding protein, to regulate apoptotic pathways. It has been implicated in both promoting and inhibiting apoptosis, depending on the specific cellular context.

Is APOOL protein expressed in specific tissues or cell types?

APOOL protein is expressed in various tissues and cell types, including the brain, neuronal cells, and immune cells. Its expression pattern suggests its involvement in multiple biological processes across different cell types.

Can APOOL protein be targeted for therapeutic interventions?

Since APOOL protein is associated with apoptotic processes and neurological disorders, it represents a potential target for therapeutic interventions. However, more research is required to develop specific strategies to modulate its activity for therapeutic purposes.

Can APOOL protein be used as a therapeutic target for cancer treatment?

While APOOL protein's involvement in apoptotic pathways makes it a potential therapeutic target for cancer treatment, further research is needed to fully understand its role in tumorigenesis and evaluate its potential as a target for therapeutic interventions.

Does APOOL protein have any known binding partners other than ALG-2?

Apart from ALG-2, APOOL protein has not been extensively studied for its interactions with other proteins. Further research is needed to explore potential additional binding partners and their biological significance.

Is APOOL protein associated with any specific disease?

Research suggests that dysregulation of APOOL protein may be involved in certain neurological disorders, including Alzheimer's disease and Parkinson's disease. However, further studies are needed to fully understand its role in disease pathology.

How was the APOOL protein discovered?

The APOOL protein was discovered through various research studies and experiments exploring the molecular mechanisms of apoptosis and calcium signaling. Its interaction with ALG-2 and its potential role in regulating apoptosis were identified through protein-protein interaction studies and functional assays.

How is APOOL protein expression regulated?

The exact mechanisms that regulate APOOL protein expression are not fully understood. However, studies suggest that it can be regulated at the transcriptional level by certain signaling pathways and transcription factors.

Is APOOL protein conserved across different species?

The APOOL protein is conserved across various species, including humans, mice, and fruit flies. This conservation suggests its biological importance and potential functional relevance in different organisms.

Is there any evidence of post-translational modifications of APOOL protein?

Limited information is available regarding post-translational modifications of APOOL protein. Further research is necessary to determine if any modifications, such as phosphorylation or ubiquitination, occur and whether they impact its function.

Are there any animal models or knockout studies for APOOL protein?

As of now, there are no specific animal models or knockout studies specifically targeting APOOL protein. However, general studies involving ALG-2 or calcium signaling components might indirectly address the functional roles of APOOL protein.

How does APOOL protein regulate calcium signaling pathways?

APOOL protein's exact role in regulating calcium signaling pathways is not fully understood. It is proposed to interact with ALG-2 and potentially modulate calcium homeostasis, but further research is needed to elucidate the underlying mechanisms.

Are there any known small molecule inhibitors or activators of APOOL protein?

Currently, no known small molecule inhibitors or activators specifically targeting APOOL protein have been reported. The development of such molecules would require further studies characterizing its function and interactions.

Are there any known interactions of APOOL protein with other proteins?

APOOL protein has been shown to interact with ALG-2, as mentioned earlier. Additionally, studies have identified potential interactions with other proteins involved in calcium signaling and apoptosis. However, more research is needed to fully characterize these interactions and their significance.