APOOL
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Official Full Name
apolipoprotein O-like
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Overview
This gene encodes a protein which contains an apolipoprotein O superfamily domain. This domain is found on proteins in circulating lipoprotein complexes. -
Synonyms
APOOL; apolipoprotein O-like; chromosome X open reading frame 33 , CXorf33, FAM121A, family with sequence similarity 121A; AAIR8193; UNQ8193; CXorf33; FAM121A; Family with sequence similarity 121A; MGC129748;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | APOOL-720H | Recombinant Human APOOL protein, GST-tagged | Wheat Germ | GST | ||
Human | APOOL-8773HCL | Recombinant Human APOOL 293 Cell Lysate | HEK293 | N/A | ||
Human | APOOL-1353HF | Recombinant Full Length Human APOOL Protein, GST-tagged | In Vitro Cell Free System | GST | 268 amino acids | |
Chicken | APOOL-1575C | Recombinant Chicken APOOL | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
APOOL involved in several pathways and played different roles in them. We selected most pathways APOOL participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with APOOL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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APOOL has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APOOL itself. We selected most functions APOOL had, and list some proteins which have the same functions with APOOL. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | E2F8;SYNPO2L;HEPACAM2;MEAF6;PID1;TBC1D19;PPP1R16B;DPH1;BAZ2A |
APOOL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOOL here. Most of them are supplied by our site. Hope this information will be useful for your research of APOOL.
BNRF1; NDUFA12
- Q&As
- Reviews
Q&As (16)
Ask a questionCurrently, there is limited information on mutations in the APOOL gene and their association with diseases. Future studies and genetic analyses might uncover potential disease-related mutations and their implications.
Currently, there is limited information on genetic variations of APOOL protein and their association with disease susceptibility. More research is required to investigate potential genetic links to diseases and understand the functional implications of these variations.
APOOL protein interacts with ALG-2, a calcium-binding protein, to regulate apoptotic pathways. It has been implicated in both promoting and inhibiting apoptosis, depending on the specific cellular context.
APOOL protein is expressed in various tissues and cell types, including the brain, neuronal cells, and immune cells. Its expression pattern suggests its involvement in multiple biological processes across different cell types.
Since APOOL protein is associated with apoptotic processes and neurological disorders, it represents a potential target for therapeutic interventions. However, more research is required to develop specific strategies to modulate its activity for therapeutic purposes.
While APOOL protein's involvement in apoptotic pathways makes it a potential therapeutic target for cancer treatment, further research is needed to fully understand its role in tumorigenesis and evaluate its potential as a target for therapeutic interventions.
Apart from ALG-2, APOOL protein has not been extensively studied for its interactions with other proteins. Further research is needed to explore potential additional binding partners and their biological significance.
Research suggests that dysregulation of APOOL protein may be involved in certain neurological disorders, including Alzheimer's disease and Parkinson's disease. However, further studies are needed to fully understand its role in disease pathology.
The APOOL protein was discovered through various research studies and experiments exploring the molecular mechanisms of apoptosis and calcium signaling. Its interaction with ALG-2 and its potential role in regulating apoptosis were identified through protein-protein interaction studies and functional assays.
The exact mechanisms that regulate APOOL protein expression are not fully understood. However, studies suggest that it can be regulated at the transcriptional level by certain signaling pathways and transcription factors.
The APOOL protein is conserved across various species, including humans, mice, and fruit flies. This conservation suggests its biological importance and potential functional relevance in different organisms.
Limited information is available regarding post-translational modifications of APOOL protein. Further research is necessary to determine if any modifications, such as phosphorylation or ubiquitination, occur and whether they impact its function.
As of now, there are no specific animal models or knockout studies specifically targeting APOOL protein. However, general studies involving ALG-2 or calcium signaling components might indirectly address the functional roles of APOOL protein.
APOOL protein's exact role in regulating calcium signaling pathways is not fully understood. It is proposed to interact with ALG-2 and potentially modulate calcium homeostasis, but further research is needed to elucidate the underlying mechanisms.
Currently, no known small molecule inhibitors or activators specifically targeting APOOL protein have been reported. The development of such molecules would require further studies characterizing its function and interactions.
APOOL protein has been shown to interact with ALG-2, as mentioned earlier. Additionally, studies have identified potential interactions with other proteins involved in calcium signaling and apoptosis. However, more research is needed to fully characterize these interactions and their significance.
Customer Reviews (4)
Write a reviewWith expert assistance and reliable product quality, researchers can conduct their experiments with confidence, enabling them to contribute to advancements in the field and potentially improve future therapeutic interventions.
This includes rigorous quality control measures to ensure the consistency and purity of the protein, thereby reducing variability in the experimental outcomes.
by utilizing APOOL protein in trials and collaborating with a supportive manufacturer, researchers can gain access to a versatile tool that can aid in their understanding of angiogenesis and vascular biology.
Their comprehensive knowledge about APOOL protein and its applications can assist researchers in optimizing protocols and ensuring reliable results.
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