Recombinant Human ARRDC3 protein, GST-tagged
Cat.No. : | ARRDC3-858H |
Product Overview : | Human ARRDC3 full-length ORF ( AAH15928, 1 a.a. - 414 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | This gene encodes a member of the arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast cancer growth and progression by binding to a phosphorylated form of integrin beta4, a tumor-related antigen, targeting the integrin for internalization and degradation. [provided by RefSeq, Jul 2016] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 71.28 kDa |
AA Sequence : | MVLGKVKSLTISFDCLNDSNVPVYS SGDTVSGRVNLEVTGEIRVKSLKIH ARGHAKVRWTESRNAGSNTAYTQNY TEEVEYFNHKDILIGHERDDDNSEE GFHTIHSGRHEYAFSFELPQTPLAT SFEGRHGSVRYWVKAELHRPWLLPV KLKKEFTVFEHIDINTPSLLSPQAG TKEKTLCCWFCTSGPISLSAKIERK GYTPGESIQIFAEIENCSSRMVVPK AAIYQTQAFYAKGKMKEVKQLVANL RGESLSSGKTETWNGKLLKIPPVSP SILDCSIIRVEYSLMVYVDIPGAMD LFLNLPLVIGTIPLHPFGSRTSSVS SQCSMNMNWLSLSLPERPEAPPSYA EVVTEEQRRNNLAPVSACDDFERAL QGPLFAYIQEFRFLPPPLYSEIDPN PDQSADDRPSCPSR |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ARRDC3 arrestin domain containing 3 [ Homo sapiens (human) ] |
Official Symbol : | ARRDC3 |
Synonyms : | ARRDC3; arrestin domain containing 3; TLIMP; arrestin domain-containing protein 3; TBP-2-like inducible membrane protein; alpha-arrestin 3 |
Gene ID : | 57561 |
mRNA Refseq : | NM_001329670 |
Protein Refseq : | NP_001316599 |
MIM : | 612464 |
UniProt ID : | Q96B67 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (11)
Ask a questionYes, ARRDC3 can be subjected to post-translational modifications, although the specific modifications are not well-documented. Phosphorylation has been reported to regulate its cellular localization and function in certain contexts.
Yes, ARRDC3 has been found to interact with proteins such as beta-arrestins, clathrin, and several G protein-coupled receptors (GPCRs). These interactions suggest its involvement in GPCR signaling and endocytic processes.
There is emerging evidence suggesting a potential role for ARRDC3 in cancer, particularly hepatocellular carcinoma (HCC). It has been found to be downregulated in HCC, and its overexpression can inhibit HCC cell proliferation and invasion.
Yes, several studies have implicated ARRDC3 in cardiac diseases, such as heart failure and arrhythmias. Its expression has been found to be altered in diseased hearts, and its overexpression has been associated with cardiac dysfunction in mouse models.
Genetic variants or mutations in the ARRDC3 gene have been reported in some studies. These variations may be associated with certain diseases or phenotypic traits, but further research is required to determine their functional significance.
ARRDC3 is evolutionarily conserved, meaning it is found in different species, including mammals, birds, and fish. The level of sequence conservation varies, with certain regions being more conserved than others.
Studies have shown that ARRDC3 can modulate the expression of genes involved in lipid metabolism and adipogenesis. It affects the differentiation of pre-adipocytes into mature adipocytes and can regulate the activity of key transcription factors involved in adipogenesis.
The role of ARRDC3 in disease is still being investigated. Some studies have suggested its involvement in cardiovascular diseases, including heart failure and arrhythmias. It has also been implicated in hepatocellular carcinoma and insulin resistance. However, more research is needed to establish the exact relationship between ARRDC3 and these pathological conditions.
ARRDC3 has the ability to interact with various proteins, including components of the endocytic machinery, membrane receptors, and adaptor proteins. These interactions likely contribute to its role in protein trafficking and signaling pathways.
The therapeutic potential of ARRDC3 is still an area of active research. Its involvement in various cellular processes and disease pathways suggests that it could be a potential target for therapeutic interventions. However, more studies are needed to uncover its precise molecular mechanisms and evaluate its viability as a therapeutic target.
The regulation of ARRDC3 expression is not well-characterized. However, studies suggest that it can be influenced by factors such as transcriptional regulation and cellular signaling pathways. Further research is needed to understand the precise mechanisms involved in the regulation of ARRDC3 expression.
Customer Reviews (3)
Write a reviewTheir unwavering commitment to customer satisfaction assures me that any challenges or queries I may encounter will be expertly resolved.
I am confident that the ARRDC3 protein will unlock vital insights into cellular processes, propelling my scientific investigations to new heights.
An additional advantage of selecting the ARRDC3 protein is the outstanding technical support offered by its manufacturer.
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