Recombinant Human ARSJ protein, GST-tagged
Cat.No. : | ARSJ-867H |
Product Overview : | Human ARSJ full-length ORF ( AAH32010.1, 1 a.a. - 85 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | Sulfatases (EC 3.1.5.6), such as ARSJ, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 35.2 kDa |
AA Sequence : | MAPGQQAMGSGTLQSSQPSECSTGN CLQEILATATGSPLSLSATWDRTGG TMNGSPCQLAKVYGFSTSQPTHMRG WTYLTGIQES |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ARSJ arylsulfatase family, member J [ Homo sapiens ] |
Official Symbol : | ARSJ |
Synonyms : | ARSJ; arylsulfatase family, member J; ASJ; arylsulfatase J; EC 3.1.6.12 |
Gene ID : | 79642 |
mRNA Refseq : | NM_024590.3 |
Protein Refseq : | NP_078866.3 |
MIM : | 610010 |
UniProt ID : | Q5FYB0 |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionCurrently, there is limited information on animal models specifically targeting the ARSJ protein. However, studies using various animal models have provided insights into the molecular processes and associated diseases affected by altered ARSJ function.
The ARSJ protein is typically found in the lysosomes, which are membrane-bound compartments within cells responsible for breaking down various molecules.
Yes, the ARSJ protein is conserved among different species, indicating its importance in sulfate metabolism throughout evolution.
Currently, there are no specific therapies targeting the ARSJ protein. However, further research may identify potential therapeutic approaches that could modulate ARSJ function in diseases associated with sulfate metabolism disturbances.
Yes, the ARSJ protein has been shown to interact with other proteins involved in sulfate metabolism, such as ARSI (arylsulfatase I) and ARSK (arylsulfatase K). These interactions likely play a role in coordinating sulfate removal in various tissues.
The regulatory mechanisms controlling ARSJ protein expression and activity are not fully understood. However, research suggests that transcriptional regulation and post-translational modifications may influence its expression and enzymatic activity.
Mutations in the ARSJ gene have been linked to a rare genetic disorder called X-linked chondrodysplasia punctata 1 (CDPX1), which is characterized by skeletal abnormalities and developmental defects.
Customer Reviews (3)
Write a reviewI highly recommend the ARSJ protein for various experimental applications.
It has demonstrated outstanding performance in ELISA, providing reliable and precise results.
I am certain that the ARSJ protein will play a pivotal role in facilitating robust and insightful research, providing the assurance of reliable and consistent results.
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