Recombinant Human ASB4 protein, GST-tagged
Cat.No. : | ASB4-893H |
Product Overview : | Human ASB4 full-length ORF (AAH25024.1, 1 a.a. - 319 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. [provided by RefSeq, Jul 2008] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 61.49 kDa |
AA Sequence : | MKLKAILIQRQIDVDTVFEVEDENM VLASYKQGYWLPSYKLKSSWATGLH LSVLFGHVECLLVLLDHNATINCRP NGKTPLHVACEMANVDCVKILCDRG AKLNCYSLSGHTALHFCTTPSSILC AKQLVWRGANVNMKTNNQDEETPLH TAAHFGLSELVAFYVEHGAIVDSVN AHMETPLAIAAYWALRFKEQEYSTE HHLVCRMLLDYKAEVNARDDDFKSP LHKAAWNCDHVLMHMMLEAGAEANL MDINGCAAIQYVLKVTSVRPAAQPE ICYQLLLNHGAARIYPPQFHKVRLC PVVSRLRKIQMAALSEISK |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ASB4 ankyrin repeat and SOCS box containing 4 [ Homo sapiens ] |
Official Symbol : | ASB4 |
Synonyms : | ASB4; ankyrin repeat and SOCS box containing 4; ankyrin repeat and SOCS box protein 4; ASB 4; ankyrin repeat and SOCS box-containing 4; ASB-4; MGC142039; MGC142041; |
Gene ID : | 51666 |
mRNA Refseq : | NM_016116 |
Protein Refseq : | NP_057200 |
MIM : | 605761 |
UniProt ID : | Q9Y574 |
Products Types
◆ Recombinant Protein | ||
ASB4-779M | Recombinant Mouse ASB4 Protein, His (Fc)-Avi-tagged | +Inquiry |
ASB4-2016M | Recombinant Mouse ASB4 Protein | +Inquiry |
ASB4-2399Z | Recombinant Zebrafish ASB4 | +Inquiry |
◆ Lysates | ||
ASB4-8662HCL | Recombinant Human ASB4 293 Cell Lysate | +Inquiry |
ASB4-8663HCL | Recombinant Human ASB4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionYes, ASB4 interacts with specific target proteins, recognizing them and facilitating their ubiquitination, leading to their subsequent degradation.
Yes, ASB4 has been observed in both the cytoplasm and the nucleus, suggesting its involvement in diverse cellular compartments and functions.
Yes, ASB4 shows evolutionary conservation, indicating its functional importance across various species.
Yes, ASB4 selectively targets certain proteins for degradation, usually by recognizing specific recognition motifs or interacting with other regulatory factors.
ASB4 can interact with various proteins, including its ubiquitin ligase complex partners or substrate proteins, influencing its activity, localization, or substrate specificity.
Currently, there are no known diseases or disorders directly linked to ASB4 dysfunction. However, its dysregulation may potentially contribute to various pathological conditions, requiring further investigation.
ASB4-mediated protein degradation can impact cellular processes such as gene expression, signal transduction, cell proliferation, and differentiation.
Yes, ASB4 has been implicated in skeletal muscle development, differentiation, and regeneration processes based on experimental evidence and studies in animal models.
Presently, there are no specific drugs targeting ASB4. However, understanding its role and identifying potential modulators may open avenues for therapeutic interventions in the future.
Yes, ASB4 expression can be regulated by external signals, including hormones, cytokines, growth factors, and cellular stress.
Customer Reviews (3)
Write a reviewThe manufacturer's outstanding technical support serves as a valuable resource, providing prompt and knowledgeable assistance whenever I encounter difficulties or require guidance.
the ASB4 protein's exceptional quality and purity guarantee its suitability for a wide range of experimental applications.
Its consistent performance and remarkable stability make it a reliable tool in studying various cellular processes and signaling pathways.
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