Recombinant Human ATP5C1 Protein, His-tagged
Cat.No. : | ATP5C1-133H |
Product Overview : | Recombinant Human ATP5C1, transcript variant 2, fused with His tag at N-terminal was expressed in E. coli. |
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Description : | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl. |
Molecular Mass : | 30 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions. |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 [ Homo sapiens ] |
Official Symbol : | ATP5C1 |
Synonyms : | ATP5C1; ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1; ATP5C, ATP5CL1; ATP synthase subunit gamma, mitochondrial; F-ATPase gamma subunit; ATP synthase gamma chain, mitochondrial; mitochondrial ATP synthase, gamma subunit 1; ATP5C; ATP5CL1; |
Gene ID : | 509 |
mRNA Refseq : | NM_005174 |
Protein Refseq : | NP_005165 |
MIM : | 108729 |
UniProt ID : | P36542 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionATP5C1 expression and function are affected by a variety of regulatory mechanisms, including regulation of transcription factors and epigenetic modifications.
Yes, ATP5C1 expression levels may be associated with the development and progression of certain diseases.
ATP5C1 is highly expressed in multiple tissues and organs, especially metabolically active tissues such as heart, liver, and brain.
Yes, ATP5C1 gene mutations are associated with certain neurological diseases such as Parkinson's disease, cerebral ischemia, etc.
It may play a role in tumor cell metabolism and energy supply.
ATP5C1 protein may be related to the occurrence and progression of metabolic diseases such as obesity and diabetes.
Customer Reviews (3)
Write a reviewThe exceptional stability of this protein makes it an invaluable tool for a wide range of applications.
Due to the wide application of proteins, researchers can conduct research in more fields and broaden the horizon of scientific research.
Because the extraordinary activity of proteins makes them valuable tools for a wide range of applications.
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