Recombinant Human CAPN2 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | CAPN2-3550H |
Product Overview : | CAPN2 MS Standard C13 and N15-labeled recombinant protein (NP_001739) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 80 kDa |
AA Sequence : | MAGIAAKLAKDREAAEGLGSHERAI KYLNQDYEALRNECLEAGTLFQDPS FPAIPSALGFKELGPYSSKTRGIEW KRPTEICADPQFIIGGATRTDICQG ALGDCWLLAAIASLTLNEEILARVV PLNQSFQENYAGIFHFQFWQYGEWV EVVVDDRLPTKDGELLFVHSAEGSE FWSALLEKAYAKINGCYEALSGGAT TEGFEDFTGGIAEWYELKKPPPNLF KIIQKALQKGSLLGCSIDITSAADS EAITFQKLVKGHAYSVTGAEEVESN GSLQKLIRIRNPWGEVEWTGRWNDN CPSWNTIDPEERERLTRRHEDGEFW MSFSDFLRHYSRLEICNLTPDTLTS DTYKKWKLTKMDGNWRRGSTAGGCR NYPNTFWMNPQYLIKLEEEDEDEED GESGCTFLVGLIQKHRRRQRKMGED MHTIGFGIYEVPEELSGQTNIHLSK NFFLTNRARERSDTFINLREVLNRF KLPPGEYILVPSTFEPNKDGDFCIR VFSEKKADYQAVDDEIEANLEEFDI SEDDIDDGFRRLFAQLAGEDAEISA FELQTILRRVLAKRQDIKSDGFSIE TCKIMVDMLDSDGSGKLGLKEFYIL WTKIQKYQKIYREIDVDRSGTMNSY EMRKALEEAGFKMPCQLHQVIVARF ADDQLIIDFDNFVRCLVRLETLFKI FKQLDPENTGTIELDLISWLCFSVL SGPTRTRPLEQKLISEEDLAANDIL DYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | CAPN2 calpain 2 [ Homo sapiens (human) ] |
Official Symbol : | CAPN2 |
Synonyms : | CAPN2; calpain 2, (m/II) large subunit; calpain-2 catalytic subunit; CANPL2; CANPml; mCANP; CANP 2; M-calpain; calpain M-type; millimolar-calpain; calpain-2 large subunit; calpain 2, large subunit; calpain large polypeptide L2; calpain, large polypeptide L2; calpain 2, large [catalytic] subunit; calcium-activated neutral proteinase 2; CANP2; FLJ39928; |
Gene ID : | 824 |
mRNA Refseq : | NM_001748 |
Protein Refseq : | NP_001739 |
MIM : | 114230 |
UniProt ID : | P17655 |
Products Types
◆ Recombinant Protein | ||
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CAPN2-0363H | Recombinant Human CAPN2 Protein, GST-Tagged | +Inquiry |
CAPN2-496H | Recombinant Human CAPN2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Capn2-759M | Recombinant Mouse Capn2 Protein, MYC/DDK-tagged | +Inquiry |
◆ Native Protein | ||
CAPN2-22P | Active Native Porcine CAPN2 protein | +Inquiry |
CAPN2-350B | Native Bovine CAPN2 | +Inquiry |
◆ Lysates | ||
CAPN2-7863HCL | Recombinant Human CAPN2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCAPN2 activity is tightly regulated by intracellular calcium levels and various other factors to maintain cellular homeostasis.
CAPN2 interacts with various cellular proteins, contributing to processes like protein degradation, cytoskeletal remodeling, and cell signaling, influencing disease pathways.
Research suggests that modulating CAPN2 activity could be a potential therapeutic strategy for managing diseases associated with its dysregulation.
Some compounds and inhibitors targeting CAPN2 have been developed in preclinical studies, showing promise in controlling its activity for therapeutic purposes.
In some cases, altered levels of CAPN2 have been observed in disease states, suggesting its potential as a biomarker, but further validation is needed.
Customer Reviews (3)
Write a reviewThe CAPN2 protein has been extensively studied and validated in various experimental applications.
Their team of technical experts possess deep knowledge and expertise regarding the protein, ensuring that researchers receive accurate and timely assistance.
In addition to its advantages in trials, the manufacturer of the CAPN2 protein offers exceptional support to researchers.
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