| Description : |
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms. |
| Protein length : |
329 amino acids |
| Molecular Weight : |
62.260kDa inclusive of tags |
| Source : |
Wheat germ |
| Tissue specificity : |
Expressed by activated B-lymphocytes and monocytes. |
| Form : |
Liquid |
| Purity : |
Proprietary Purification |
| Storage buffer : |
pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
| Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequences of amino acids : |
MDPQCTMGLSNILFVMAFLLSGAAPLKIQAYFNETADLPC QFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSV HSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPT GMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLT CSSIHGYPEPKKMSVLLRTKNSTIEYDGIMQKSQDNVTEL YDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSI ELEDPQPPPDHIPWITAVLPTVIICVMVFCLILWKWKKKK RPRNSYKCGTNTMEREESEQTKKREKIHIPERSDETQR VFKSSKTSSCDKSDTCF |
| Sequence Similarities : |
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
