Recombinant Human CDK4 protein, His-tagged
Cat.No. : | CDK4-2678H |
Product Overview : | Recombinant Human CDK4 protein(P11802)(2-303aa), fused to N-terminal His tag, was expressed in E. coli. |
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Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Molecular Mass : | 37.6 kDa |
Protein length : | 2-303aa |
AA Sequence : | ATSRYEPVAEIGVGAYGTVYKARDP HSGHFVALKSVRVPNGGGGGGGLPI STVREVALLRRLEAFEHPNVVRLMD VCATSRTDREIKVTLVFEHVDQDLR TYLDKAPPPGLPAETIKDLMRQFLR GLDFLHANCIVHRDLKPENILVTSG GTVKLADFGLARIYSYQMALTPVVV TLWYRAPEVLLQSTYATPVDMWSVG CIFAEMFRRKPLFCGNSEADQLGKI FDLIGLPPEDDWPRDVSLPRGAFPP RGPRPVQSVVPEMEESGAQLLLEML TFNPHKRISAFRALQHSYLHKDEGN PE |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Reconstitution : | Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. |
Gene Name : | CDK4 cyclin-dependent kinase 4 [ Homo sapiens ] |
Official Symbol : | CDK4 |
Synonyms : | CDK4; cyclin-dependent kinase 4; PSK J3; cell division protein kinase 4; CMM3; PSK-J3; MGC14458; |
Gene ID : | 1019 |
mRNA Refseq : | NM_000075 |
Protein Refseq : | NP_000066 |
MIM : | 123829 |
UniProt ID : | P11802 |
Products Types
◆ Recombinant Protein | ||
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CDK4/CCND3-275H | Recombinant Human CDK4/CCND3, GST-tagged, Active | +Inquiry |
CDK4-1525M | Recombinant Mouse CDK4 Protein, His (Fc)-Avi-tagged | +Inquiry |
CDK4-3139H | Recombinant Human CDK4 Protein, MYC/DDK-tagged | +Inquiry |
CDK4-962R | Recombinant Rat CDK4 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CDK4-664HCL | Recombinant Human CDK4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionResistance to CDK4 inhibitors and the need for patient stratification are some of the challenges in using CDK4 as a therapeutic target.
Yes, CDK4 is a target for cancer therapy, and drugs that inhibit CDK4 have been developed for the treatment of specific cancers.
CDK4 is clinically relevant because it plays a crucial role in the development and progression of various cancers.
CDK4 overactivity is commonly associated with breast cancer, melanoma, and liposarcoma.
CDK4 can promote cell senescence, a state of irreversible growth arrest, which has implications in cancer therapy.
Customer Reviews (3)
Write a reviewWhether it's troubleshooting experimental issues, providing guidance on experimental design, or answering any inquiries related to the CDK4 protein, the manufacturer is committed to helping researchers overcome challenges and achieve their scientific goals.
They actively seek feedback and incorporate it into their product development process, continuously improving the quality and performance of the CDK4 protein.
The manufacturer also values customer satisfaction and strives to maintain a strong relationship with researchers.
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