Recombinant Human CDK4 protein, T7-tagged
Cat.No. : | CDK4-191H |
Product Overview : | Recombinant human CDK4 (303 aa) protein fused with T7 Tag at N-terminal was expressed in E. coli. |
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Source : | E. coli |
Species : | Human |
Tag : | T7 |
Form : | 0.5 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, arginine, DTT and Glycerol. |
AA Sequence : | MASMTGGQQMGRGEFMATSRYEPVA EIGVGAYGTVYKARDPHSGHFVALK SVRVPNGGGGGGGLPISTVREVALL RRLEAFEHPNVVRLMDVCATSRTDR EIKVTLVFEHVDQDLRTYLDKAPPP GLPAETIKDLMRQFLRGLDFLHANC IVHRDLKPENILVTSGGTVKLADFG LARIYSYQMALTPVVVTLWYRAPEV LLQSTYATPVDMWSVGCIFAEMFRR KPLFCGNSEADQLGKIFDLIGLPPE DDWPRDVSLPRGAFPPRGPRPVQSV VPEMEESGAQLLLEMLTFNPHKRIS AFRALQHSYLHKDEGNPE |
Purity : | >90% by SDS-PAGE. |
Storage : | Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days. |
Gene Name : | CDK4 cyclin-dependent kinase 4 [ Homo sapiens ] |
Official Symbol : | CDK4 |
Synonyms : | CDK4; cyclin-dependent kinase 4; PSK J3; cell division protein kinase 4; CMM3; PSK-J3; MGC14458; |
Gene ID : | 1019 |
mRNA Refseq : | NM_000075 |
Protein Refseq : | NP_000066 |
MIM : | 123829 |
UniProt ID : | P11802 |
Chromosome Location : | 12q13 |
Pathway : | ATF-2 transcription factor network, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; |
Function : | ATP binding; cyclin-dependent protein kinase activity; nucleotide binding; protein binding; protein kinase activity; |
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◆ Lysates | ||
CDK4-664HCL | Recombinant Human CDK4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionResistance to CDK4 inhibitors and the need for patient stratification are some of the challenges in using CDK4 as a therapeutic target.
Yes, CDK4 is a target for cancer therapy, and drugs that inhibit CDK4 have been developed for the treatment of specific cancers.
CDK4 is clinically relevant because it plays a crucial role in the development and progression of various cancers.
CDK4 overactivity is commonly associated with breast cancer, melanoma, and liposarcoma.
CDK4 can promote cell senescence, a state of irreversible growth arrest, which has implications in cancer therapy.
Customer Reviews (3)
Write a reviewWhether it's troubleshooting experimental issues, providing guidance on experimental design, or answering any inquiries related to the CDK4 protein, the manufacturer is committed to helping researchers overcome challenges and achieve their scientific goals.
They actively seek feedback and incorporate it into their product development process, continuously improving the quality and performance of the CDK4 protein.
The manufacturer also values customer satisfaction and strives to maintain a strong relationship with researchers.
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