| Description : |
This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
33.3 kDa |
| AA Sequence : |
MQKYEKLEKIGEGTYGTVFKAKNRE THEIVALKRVRLDDDDEGVPSSALR EICLLKELKHKNIVRLHDVLHSDKK LTLVFEFCDQDLKKYFDSCNGDLDP EIVKSFLFQLLKGLGFCHSRNVLHR DLKPQNLLINRNGELKLADFGLARA FGIPVRCYSAEVVTLWYRPPDVLFG AKLYSTSIDMWSAGCIFAELANAGR PLFPGNDVDDQLKRIFRLLGTPTEE QWPSMTKLPDYKPYPMYPATTSLVN VVPKLNATGRDLLQNLLKCNPVQRI SAEEALQHPYFSDFCPPTRTRPLEQ KLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
