Recombinant Human CDK6, His-tagged
Cat.No. : | CDK6-27908TH |
Product Overview : | Recombinant full length Human Cdk6 with N-terminal His tag expressed by baculovirus in Sf9 insect cells, MWt 39kDa. |
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Description : | The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
Conjugation : | HIS |
Form : | Liquid |
Purity : | >90% by SDS-PAGE |
Storage buffer : | Preservative: 150mM ImidazoleConstituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 0.2mM DTT, 0.1mM PMSF, pH 7.0 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Contains 1 protein kinase domain. |
Gene Name : | CDK6 cyclin-dependent kinase 6 [ Homo sapiens ] |
Official Symbol : | CDK6 |
Synonyms : | CDK6; cyclin-dependent kinase 6; PLSTIRE; |
Gene ID : | 1021 |
mRNA Refseq : | NM_001145306 |
Protein Refseq : | NP_001138778 |
MIM : | 603368 |
Uniprot ID : | Q00534 |
Chromosome Location : | 7q21-q22 |
Pathway : | B Cell Receptor Signaling Pathway, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem; |
Function : | ATP binding; cyclin binding; cyclin-dependent protein kinase activity; nucleotide binding; protein binding; |
Products Types
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CDK6-1032H | Active Recombinant Human CDK6 Protein, GST-Tagged | +Inquiry |
CDK6/CCND3-278H | Recombinant Human CDK6/CCND3, His-tagged, Active | +Inquiry |
CDK6-27H | Recombinant Human CDK6/CCND2 Protein (Full length), N-GST-tagged | +Inquiry |
CDK6/CCND1-277H | Recombinant Human CDK6/CCND1, His-tagged, GST-tagged, Active | +Inquiry |
◆ Lysates | ||
CDK6-7622HCL | Recombinant Human CDK6 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe expression level of CDK6 is regulated by a variety of factors, including transcription factors, epigenetic modifications, and signal transduction pathways. These factors can affect the transcription and translation processes of the CDK6 gene, thereby regulating its expression level in cells.
There are several challenges in the development of CDK6 inhibitors, including issues such as inhibitor selectivity, drug resistance, and drug delivery. In addition, since CDK6 also has a certain function in normal cells, the side effects of inhibitors are also a factor to consider.
It plays an important role in stem cell biology. It is involved in the process of self-renewal and differentiation of stem cells, as well as in determining the fate of stem cells. By regulating the activity of CDK6, it is possible to influence the proliferation and fate selection of stem cells.
CDK6 inhibitors have been developed as potential anti-cancer drugs and have shown some efficacy in clinical trials. They block the progression of the cell cycle by inhibiting the activity of CDK6, thereby inhibiting the proliferation of cancer cells.
The activity of CDK6 is regulated at multiple levels, including binding to other cyclins and inhibitors, phosphorylation and dephosphorylation events, and transcriptional and post-translational modifications.
The role of CDK6 in different types of cancer may vary. It may act as a promoter in some cancers and as a suppressant in others. This difference can be related to factors such as the type, stage, and genetic background of the cancer.
Customer Reviews (3)
Write a reviewThe results obtained after analysis by SDS-PAGE or Western blot were good.
It has a wide range of applications and can be used in various biological experiments.
The purity of CDK6 is good, and the experimental results obtained are very accurate.
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