Recombinant Human CHAT Protein Pre-coupled Magnetic Beads

• Cat.No.: CHAT-2666H-B
• Product Overview: The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations.

Specification

• Source: HEK293
• Species: Human
• Form: Solution
• Particle size: ~2 μm
• Beads Surface: Hydrophilic
• Capacity: > 200 pmol rabbit IgG/ mg beads
• Applications: Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification.
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions.
• Storage: 2-8℃. Do not to freeze thaw the Beads
• Concentration: 10mg beads/mL
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: CHAT choline O-acetyltransferase [ Homo sapiens ]
• Official Symbol: CHAT
• Gene ID: 1103
• mRNA Refseq: NM_001142929.1
• Protein Refseq: NP_001136401.1
• MIM: 118490
• UniProt ID: D3DX95

Reviews

10/15/2022

The resolution of CHAT in Western blot is high and can distinguish between similar protein molecular weights.

02/14/2021

This repeatability of CHAT is very good, which can greatly reduce the experimental error and allow me to evaluate the experimental results more accurately.

04/25/2019

Stability of CHAT is so good that a variety of experimental manipulations can be performed without concern for changes and effects on its properties.

Q&As

How to use the activity of CHAT protein for disease treatment?

The activity of the CHAT protein can be modulated by drugs or other small molecule compounds to treat neurological disorders associated with CHAT protein abnormalities. For example, some drugs can promote the expression and activity of the CHAT protein, thereby increasing acetylcholine synthesis.

How is the expression level of CHAT protein regulated?

Expression level of CHAT protein is regulated by a variety of factors, including gene expression, post-transcriptional modifications, nutritional status, etc. Some drugs or other small molecule compounds can also affect their expression levels by regulating gene expression or post-transcriptional modifications.

What diseases are mutations or abnormal expression of the CHAT protein associated with?

Some studies have shown that mutations or abnormal expression of the CHAT protein may be related to neurological diseases, psychiatric diseases, etc. However, further research is needed to confirm the association.

How are CHAT proteins related to other neurotransmitters or signaling molecules?

CHAT protein has some association with other neurotransmitters or signaling molecules. For example, it can interact with cholinergic neurons to co-regulate acetylcholine synthesis and release. In addition, it can interact with other neurotransmitters or signaling molecules such as dopamine, glutamate, etc.

How to use CHAT protein for disease diagnosis?

The occurrence, progression and prognosis of neurological diseases can be assessed by detecting characteristics such as the expression level, activity and interaction of CHAT protein with other proteins. These features can also be used to develop new biomarkers and drug targets.

Why are CHAT proteins linked to disease development and progression?

Some studies have shown that abnormal expression of CHAT protein may be related to the occurrence and progression of some neurological diseases, such as Alzheimer's disease and Parkinson's disease. In addition, the CHAT protein may also be a drug target for the treatment of these diseases.