Recombinant Human CSF2RA Protein, C-His-tagged

• Cat.No.: CSF2RA-021H
• Product Overview: Recombinant Human CSF2RA Protein with C-His tag was expressed in E. coli.

Specification

• Description: Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (GM-CSF Receptor α), also known as CSF2RA and CD116, is a type 1 transmembrane protein with low affinity for GM-CSF. GM-CSF Receptor α is primarily expressed on myeloid cells, including granulocytes, monocytes, macrophages, and dendritic cells. GM-CSF Receptor α forms a heterodimeric receptor complex with GM-CSF Receptor β, creating the high affinity GM-CSF receptor. Upon dimerization and ligand binding, the β subunit becomes phosphorylated and transduces signals via Jak/STAT and MAPK pathways for cell proliferation, differentiation, and survival. Oligomerization of the high affinity GM-CSF Receptor α/β complex is required for optimal intracellular signal transduction. Soluble GM-CSF Receptor α, either secreted or cleaved from the cell surface, can competitively bind GM-CSF, preventing membrane receptor signaling. Multiple isoforms of GM-CSF Receptor α have been described.
• Source: E. coli
• Species: Human
• Tag: C-His
• Molecular Mass: ~33 kDa
• AA Sequence: EKSDLRTVAPASSLNVRFDSRTMNL SWDCQENTTFSKCFLTDKKNRVVEP RLSNNECSCTFREICLHEGVTFEVH VNTSQRGFQQKLLYPNSGREGTAAQ NFSCFIYNADLMNCTWARGPTAPRD VQYFLYIRNSKRRREIRCPYYIQDS GTHVGCHLDNLSGLTSRNYFLVNGT SREIGIQFFDSLLDTKKIERFNPPS NVTVRCNTTHCLVRWKQPRTYQKLS YLDFQYQLDVHRKNTQPGTENLLIN VSGDLENRYNFPSSEPRAKHSVKIR AADVRILNWSSWSEAIEFGSDDG
• Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
• Notes: For research use only, not for use in diagnostic procedure.
• Storage: Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
• Concentration: ≥0.5 mg/mL
• Storage Buffer: PBS, 4M Urea, pH7.4

Gene Information

• Gene Name: CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) [ Homo sapiens (human) ]
• Official Symbol: CSF2RA
• Synonyms: CSF2RA; colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage); CSF2R; granulocyte-macrophage colony-stimulating factor receptor subunit alpha; CD116; GMR-alpha; GMCSFR-alpha; CD116 antigen; GM-CSF receptor alpha subunit; colony stimulating factor 2 receptor alpha subunit; granulocyte-macrophage colony-stimulating factor receptor alpha chain; GMR; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; MGC3848; MGC4838; GM-CSF-R-alpha
• Gene ID: 1438
• mRNA Refseq: NM_001161529
• Protein Refseq: NP_001155001
• MIM: 306250
• UniProt ID: P15509