Recombinant Human Cyclin-Dependent Kinase 9, GST-tagged, Active
Cat.No. : | CDK9-280H |
Product Overview : | Recombinant human full-length CDK9 and CyclinK were co-expressed by baculovirus inSf9insect cells using an N-terminal GST tag on both proteins. MW=68 kDa and CyclinK~67 kDa. |
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Cat. No. : | CDK9-280H |
Description : | CDK9/CyclinK is a member of the cyclin-dependent protein kinase (CDK) family. CDK9 is closely related to cdc28 and cdc2 and is an important regulator of the cell cycle. CDK9 is a component of the multiprotein complex TAK/P-TEFβ. CDK9 can modulate RNA polymerase II-directed transcription by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. CDK9 forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. CDK9 also interacts with the HIV-1 Tat protein which suggested a possible involvement of this protein in AIDS. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | Full-length. |
Applications : | Kinase Assay, Western Blot. |
Purity : | Sample Purity Data. For specific information on a given lot, see related technical data sheet. |
Storage And Stability : | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | CDK9 cyclin-dependent kinase 9 [ Homo sapiens ] |
Synonyms : | CDK9; cyclin-dependent kinase 9; TAK; C-2k; CTK1; CDC2L4; PITALRE; cyclin-dependent kinase 9 (CDC2-related kinase);Cell division protein kinase 9;EC2.7.11.22;EC2.7.11.23; Cyclin-dependent kinase 9; Serine/threonine-protein kinase; Cell division cycle 2-like protein kinase 4 |
Gene ID : | 1025 |
mRNA Refseq : | NM_001261 |
Protein Refseq : | NP_001252 |
UniProt ID : | P50750 |
Chromosome Location : | 9q34.1 |
MIM : | 603251 |
Pathway : | Gene Expression; HIV Infection; Transcription |
Function : | ATP binding; DNA binding; RNA polymerase II carboxy-terminal domain kinase activity; cyclin-dependent protein kinase activity; nucleotide binding; protein binding; snRNA binding; transferase activity |
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◆ Lysates | ||
CDK9-178HCL | Recombinant Human CDK9 lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionBesides cancer and antiviral therapies, CDK9 is being explored for its role in other diseases, including neurodegenerative disorders.
Yes, combination therapies involving CDK9 inhibitors and other drugs are being investigated to enhance treatment outcomes.
CDK9 expression tends to increase as cancer progresses, suggesting its potential as a biomarker for disease severity.
CDK9 inhibitors can impact normal cell functions, leading to potential side effects such as myelosuppression.
Yes, several clinical trials are exploring the effectiveness of CDK9 inhibitors in different cancer types.
Customer Reviews (3)
Write a reviewIts remarkable quality, versatility, and the manufacturer's commitment to customer satisfaction make it the perfect choice for researchers seeking a premier protein that will undoubtedly enhance their experimental endeavors.
In addition to its remarkable quality and exceptional technical support, the CDK9 Protein boasts an impressive range of applications.
The CDK9 Protein has exceeded my expectations by consistently delivering outstanding results and providing exceptional technical support.
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