Recombinant Human Desmoglein 1

• Cat.No.: DSG1-1601H

Specification

• Cat. No.: DSG1-1601H
• Description: Desmoglein 1, also known as DSG1, is a human gene. Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. DGI expression may be a significant factor for invasion, metastasis, and prognosis of human esophageal cancer.
• Molecular Weight: The predicted molecular weight of Recombinant Human Desmoglein-1 is Mr 82 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 110 kDa.
• Source: Mammalian cells
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70℃. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: DSG1 desmoglein 1 [ Homo sapiens ]
• Synonyms: DSG1; desmoglein 1; DG1; DSG; CDHF4; PPKS1; SPPK1; desmosomal glycoprotein 1; pemphigus foliaceus antigen; Desmoglein-1; DGI
• Gene ID: 1828
• mRNA Refseq: NM_001942
• Protein Refseq: NP_001933
• MIM: 125670
• UniProt ID: Q02413
• Chromosome Location: 18q12.1
• Function: calcium ion binding; protein binding; toxin binding

Reviews

02/22/2023

Its impeccable purity and integrity make it a valuable asset in my research endeavors.

03/02/2022

Their team of experts has been instrumental in resolving any queries or challenges I encountered regarding the application and utilization of the DSG1 protein.

03/22/2021

The DSG1 protein surpasses expectations in terms of quality and is an ideal match for my experimental requirements.

Q&As

How is DSG1 expression regulated in the skin?

Various factors, including cytokines and growth factors, can regulate the expression of DSG1 in skin cells.

Are there any clinical trials focused on DSG1 protein therapies?

Some clinical trials may be exploring DSG1-based therapies for skin disorders, but you should consult clinical trial databases for specific information.

What other medical conditions are associated with DSG1 protein?

DSG1 abnormalities are primarily linked to skin disorders, but some studies suggest potential connections to oral mucosa disorders.

Can DSG1 be used as a biomarker for skin cancer?

While DSG1 is not a direct biomarker for skin cancer, its expression levels may be altered in some skin cancers.

Can DSG1-targeted therapies be used to treat skin conditions?

Research is ongoing, but DSG1-targeted therapies have the potential to treat conditions related to DSG1 deficiencies.