Recombinant Human DFFA Protein (Met1-Thr331), N-His tagged
Cat.No. : | DFFA-1956H |
Product Overview : | Recombinant human DFFA (Met1-Thr331) fused with N-terminal His tag was expressed in E. coli. |
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Source : | E. coli |
Species : | Human |
Tag : | N-His |
Form : | Lyophilized powder/frozen liquid |
Molecular Mass : | 36.41 kDa |
Protein Length : | Met1-Thr331 |
Purity : | >90% as determined by SDS-PAGE |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | Supplied as solution form in PBS or lyophilized from PBS. |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name : | DFFA DNA fragmentation factor, 45kDa, alpha polypeptide [ Homo sapiens (human) ] |
Official Symbol : | DFFA |
Synonyms : | DFFA; DNA fragmentation factor, 45kDa, alpha polypeptide; DNA fragmentation factor, 45 kD, alpha polypeptide; DNA fragmentation factor subunit alpha; DFF 45; DFF1; DFF45; DNA fragmentation factor; 45 kD; alpha subunit; ICAD; inhibitor of CAD; DNA fragmentation factor 45 kDa subunit; DFF-45; |
Gene ID : | 1676 |
mRNA Refseq : | NM_004401 |
Protein Refseq : | NP_004392 |
MIM : | 601882 |
UniProt ID : | O00273 |
Products Types
◆ Recombinant Protein | ||
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DFFA-1074R | Recombinant Rhesus Macaque DFFA Protein, His (Fc)-Avi-tagged | +Inquiry |
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DFFA-30138H | Recombinant Human DFFA protein, GST-tagged | +Inquiry |
◆ Lysates | ||
DFFA-6967HCL | Recombinant Human DFFA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionDysregulation or abnormal expression of DFFA is associated with various conditions, including cancer and neurodegenerative disorders, highlighting its role in apoptotic dysfunction.
DFFA contributes to DNA fragmentation and chromatin condensation by being cleaved and activated by caspases, particularly caspase-3, during apoptotic cell death.
DFFA is predominantly localized in the nucleus, specifically during the initiation of apoptosis, where it actively participates in chromatin condensation and DNA fragmentation.
There are potential therapeutic implications related to DFFA in diseases involving apoptotic dysregulation and abnormal cell survival, making it a target for drug development.
DNA Fragmentation Factor Subunit Alpha (DFFA) plays a crucial role in cellular processes, primarily contributing to the execution of apoptosis and programmed cell death.
DFFA actively participates in regulating the balance between cell survival and programmed cell death in various tissues, influencing tissue homeostasis.
Specific caspases, including caspase-3, activate DFFA, influencing its role in the execution phase of apoptosis and facilitating efficient DNA degradation.
Customer Reviews (3)
Write a reviewWe felt well-supported throughout our usage of the product, thanks to the dedicated customer service.
Consistency in the product's behavior across experimental conditions enhanced the credibility of our findings.
The product's adaptability to various buffers contributed to its stable and reliable performance.
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