Recombinant Human DISC1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: DISC1-6678H
• Product Overview: DISC1 MS Standard C13 and N15-labeled recombinant protein (NP_061132) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 93.4 kDa
• AA Sequence: MPGGGPQGAPAAAGGGGVSHRAGSR DCLPPAACFRRRRLARRPGYMRSST GPGIGFLSPAVGTLFRFPGGVSGEE SHHSESRARQCGLDSRGLLVRSPVS KSAAAPTVTSVRGTSAHFGIQLRGG TRLPDRLSWPCGPGSAGWQQEFAAM DSSETLDASWEAACSDGARRVRAAG SLPSAELSSNSCSPGCGPEVPPTPP GSHSAFTSSFSFIRLSLGSAGERGE AEGCPPSREAESHCQSPQEMGAKAA SLDGPHEDPRCLSRPFSLLATRVSA DLAQAARNSSRPERDMHSLPDMDPG SSSSLDPSLAGCGGDGSSGSGDAHS WDTLLRKWEPVLRDCLLRNRRQMEV ISLRLKLQKLQEDAVENDDYDKAET LQQRLEDLEQEKISLHFQLPSRQPA LSSFLGHLAAQVQAALRRGATQQAS GDDTHTPLRMEPRLLEPTAQDSLHV SITRRDWLLQEKQQLQKEIEALQAR MFVLEAKDQQLRREIEEQEQQLQWQ GCDLTPLVGQLSLGQLQEVSKALQD TLASAGQIPFHAEPPETIRSLQERI KSLNLSLKEITTKVCMSEKFCSTLR KKVNDIETQLPALLEAKMHAISGNH FWTAKDLTEEIRSLTSEREGLEGLL SKLLVLSSRNVKKLGSVKEDYNRLR REVEHQETAYETSVKENTMKYMETL KNKLCSCKCPLLGKVWEADLEACRL LIQSLQLQEARGSLSVEDERQMDDL EGAAPPIPPRLHSEDKRKTPLKVLE EWKTHLIPSLHCAGGEQKEESYILS AELGEKCEDIGKKLLYLEDQLHTAI HSHDEDLIQSLRRELQMVKETLQAM ILQLQPAKEAGEREAAASCMTAGVH EAQATRTRPLEQKLISEEDLAANDI LDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: DISC1 disrupted in schizophrenia 1 [ Homo sapiens (human) ]
• Official Symbol: DISC1
• Synonyms: DISC1; disrupted in schizophrenia 1; disrupted in schizophrenia 1 protein; SCZD9; C1orf136; FLJ13381; FLJ21640; FLJ25311; FLJ41105; KIAA0457
• Gene ID: 27185
• mRNA Refseq: NM_018662
• Protein Refseq: NP_061132
• MIM: 605210
• UniProt ID: Q9NRI5