Recombinant Human DNM1 Protein (2-245 aa), His-tagged

• Cat.No.: DNM1-1380H
• Product Overview: Recombinant Human DNM1 Protein (2-245 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Neuroscience. Protein Description: Partial.

Specification

• Description: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
• Source: Yeast
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 28.7 kDa
• Protein length: 2-245 aa
• AA Sequence: GNRGMEDLIPLVNRLQDAFSAIGQN ADLDLPQIAVVGGQSAGKSSVLENF VGRDFLPRGSGIVTRRPLVLQLVNA TTEYAEFLHCKGKKFTDFEEVRLEI EAETDRVTGTNKGISPVPINLRVYS PHVLNLTLVDLPGMTKVPVGDQPPD IEFQIRDMLMQFVTKENCLILAVSP ANSDLANSDALKVAKEVDPQGQRTI GVITKLDLMDEGTDARDVLENKLLP LRRGYIGVVNRSQKDIDGK
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: DNM1 dynamin 1 [ Homo sapiens ]
• Official Symbol: DNM1
• Synonyms: DNM1; dynamin 1; DNM; dynamin-1
• Gene ID: 1759
• mRNA Refseq: NM_001005336
• Protein Refseq: NP_001005336
• MIM: 602377
• UniProt ID: Q05193

Reviews

09/06/2022

Precise protein quantification, ensures data accuracy in our experiments.

05/26/2021

Accurate mass spectrometry, essential for precise proteomics analysis.

03/06/2021

Efficient peptide synthesis, accelerates our peptide research efficiently.

Q&As

How does DNM1 contribute to the development and maintenance of neural networks?

DNM1 contributes to the formation and maintenance of neural circuits, essential for brain function.

What role does DNM1 play in endocytosis and membrane trafficking within cells?

DNM1 plays a key role in endocytosis, facilitating membrane trafficking and cellular transport processes.

What are the mechanisms by which DNM1 modulates synaptic plasticity and learning?

DNM1 regulates synaptic plasticity, crucial for learning and memory formation.

How do alterations in DNM1 expression or function affect neurodegenerative diseases?

Changes in DNM1 function can influence the progression of neurodegenerative diseases, affecting neuronal health and connectivity.

How does DNM1 (Dynamin 1) regulate synaptic vesicle recycling and neurotransmitter release in neurons?

DNM1 is crucial for synaptic vesicle recycling, controlling neurotransmitter release at synapses.

How does DNM1 influence cellular signaling pathways, particularly in the nervous system?

DNM1 impacts cellular signaling in neurons, influencing various neuronal activities and responses.

What is the impact of DNM1 mutations on neurological disorders, such as epilepsy?

Mutations in DNM1 are linked to neurological conditions like epilepsy, affecting synaptic function.