Recombinant Human DNM1L Protein (1-710 aa), His-Myc-tagged
Cat.No. : | DNM1L-2584H |
Product Overview : | Recombinant Human DNM1L Protein (1-710 aa) is produced by E. coli expression system. This protein is fused with a 10xHis tag at the N-terminal and a Myc tag at the C-terminal. Research Area: Cancer. Protein Description: Full Length of Isoform 2. |
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Description : | Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Plays an important role in mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution. |
Source : | E. coli |
Species : | Human |
Tag : | His-Myc |
Form : | Tris-based buffer,50% glycerol |
Molecular Mass : | 84.4 kDa |
Protein length : | 1-710 aa |
AA Sequence : | MEALIPVINKLQDVFNTVGADIIQL PQIVVVGTQSSGKSSVLESLVGRDL LPRGTGIVTRRPLILQLVHVSQEDK RKTTGEENGVEAEEWGKFLHTKNKL YTDFDEIRQEIENETERISGNNKGV SPEPIHLKIFSPNVVNLTLVDLPGM TKVPVGDQPKDIELQIRELILRFIS NPNSIILAVTAANTDMATSEALKIS REVDPDGRRTLAVITKLDLMDAGTD AMDVLMGRVIPVKLGIIGVVNRSQL DINNKKSVTDSIRDEYAFLQKKYPS LANRNGTKYLARTLNRLLMHHIRDC LPELKTRINVLAAQYQSLLNSYGEP VDDKSATLLQLITKFATEYCNTIEG TAKYIETSELCGGARICYIFHETFG RTLESVDPLGGLNTIDILTAIRNAT GPRPALFVPEVSFELLVKRQIKRLE EPSLRCVELVHEEMQRIIQHCSNYS TQELLRFPKLHDAIVEVVTCLLRKR LPVTNEMVHNLVAIELAYINTKHPD FADACGLMNNNIEEQRRNRLARELP SAVSRDKLIQDSRRETKNVASGGGG VGDGVQEPTTGNWRGMLKTSKAEEL LAEEKSKPIPIMPASPQKGHAVNLL DVPVPVARKLSAREQRDCEVIERLI KSYFLIVRKNIQDSVPKAVMHFLVN HVKDTLQSELVGQLYKSSLLDDLLT ESEDMAQRRKEAADMLKALQGASQI IAEIRETHLW |
Purity : | > 85% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA will be sent along with the products. Please refer to it for detailed information. |
Gene Name : | DNM1L dynamin 1-like [ Homo sapiens ] |
Official Symbol : | DNM1L |
Synonyms : | DNM1L; dynamin 1-like; dynamin-1-like protein; DRP1; DVLP; DYMPLE; HDYNIV; VPS1; DLP1; EMPF; DYNIV-11; FLJ41912; |
Gene ID : | 10059 |
mRNA Refseq : | NM_005690 |
Protein Refseq : | NP_005681 |
MIM : | 603850 |
UniProt ID : | O00429 |
Products Types
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DNM1L-8493H | Active Recombinant Human DNM1L Protein, Myc/DDK-tagged | +Inquiry |
DNM1L-1582R | Recombinant Rat DNM1L Protein, His (Fc)-Avi-tagged | +Inquiry |
DNM1L-777H | Recombinant Human DNM1L Protein, His (Fc)-Avi-tagged | +Inquiry |
Dnm1l-2618M | Recombinant Mouse Dnm1l Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
DNM1L-6858HCL | Recombinant Human DNM1L 293 Cell Lysate | +Inquiry |
DNM1L-6859HCL | Recombinant Human DNM1L 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionA mutation in the DNM1L gene may have a genetic predisposition, meaning that the mutation is more likely to occur in a patient's family member.
DNM1L is involved in the regulation of neuronal connections and synaptic function, especially in the endocytosis and release process of synaptic vesicles, thereby affecting the transmission of neural signals.
DNM1L gene mutations can be transmitted in different genetic ways such as autosomal dominant, dominant negative, and dominant homosexual, depending on the type and location of the mutation.
DNM1L gene mutations are associated with a number of neurological-related diseases, including Charcot-Marie-Tooth disease, multiple system atrophy, intellectual disability, and movement disorders.
Mutations in the DNM1L gene may be associated with neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease and Huntington's disease.
Through long-term follow-up and clinical data analysis of patients, the impact of DNM1L gene mutations on disease prognosis, such as age of onset, disease progression and quality of life, can be evaluated.
Customer Reviews (3)
Write a reviewIncrease yield and purity and improve production efficiency in biotechnology production.
Good fluorescence labeling performance in light microscopy technology, which is helpful for cell imaging studies.
In vaccine research, it has been found that it can induce immune protective effect and has potential for disease prevention.
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