Recombinant Human Dot1L (1-416) Protein

• Cat.No.: DOT1L3226H

Specification

• Description: Dot1L was expressed and purified from E. coli. The protein was expressed as a GST-fusion protein and purified by a 3-step chromatographic procedure comprising affinity, ion exchange and size exclusion chromatography steps.
• Species: Human
• Molecular Mass: 40.7 kDa
• Purity: > 95%
• Storage: frozen; -80
• Storage Buffer: 20 mM TrisCl pH = 8.0;200 mM NaCl;1 mM EDTA;1 mM DTT

Gene Information

• Gene Name: Dot1L (1-416)
• Official Symbol: DOT1L
• Synonyms: Dipeptidyl Peptidase 4; Adenosine Deaminase Complexing Protein 2; Dipeptidylpeptidase IV (CD26; Adenosine Deaminase Complexing Protein 2); T-Cell Activation Antigen CD26; Dipeptidyl Peptidase IV; EC 3.4.14.5; DPP IV; ADCP-2; ADCP2
• Gene ID: 84444
• UniProt ID: Q8TEK3

Reviews

11/04/2022

Efficient protein purification, consistently delivers high yield and purity.

11/21/2020

Precise protein quantification, ensures data precision in our experiments.

02/11/2018

Dependable peptide synthesis, accelerates our peptide-focused projects effectively.

Q&As

What are the mechanisms by which DOT1L modulates transcriptional regulation in various cell types?

DOT1L modulates transcriptional regulation, affecting gene expression patterns in different cell types.

How do alterations in DOT1L expression or activity affect cellular aging and the development of age-related diseases?

Variations in DOT1L activity impact cellular aging and may contribute to age-related diseases.

How does DOT1L influence embryonic development and stem cell differentiation?

DOT1L influences embryonic development and stem cell differentiation through epigenetic regulation.

How does DOT1L contribute to the pathogenesis of leukemia, particularly MLL-rearranged leukemia?

DOT1L contributes to leukemia development, especially in MLL-rearranged cases, by altering gene expression.

How does DOT1L (Disruptor of Telomeric Silencing 1-Like) regulate histone methylation and gene expression?

DOT1L regulates gene expression by methylating histone H3, affecting chromatin and gene activity.

What role does DOT1L play in the development and maintenance of chromatin structure?

DOT1L plays a crucial role in chromatin structure and stability, influencing genomic integrity.

What is the impact of DOT1L inhibition on epigenetic therapies for cancer treatment?

Inhibiting DOT1L shows promise in epigenetic cancer therapies by modifying disease-related gene expression.